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- W2605427859 abstract "Seven derivatives of 2-diphenylmethoxyethylamines and six of 3-(diphenylmethoxy)-propylamines were synthesized and their papaverine-like antispasmodic activity was tested on some smooth muscle preparations such as rat uterus, mouse intestine, and guinea pig tracheal muscle. The index of thermodynamic activity of these compounds was obtained from the potency ratio and solubility of the bases in water. The ω-(diphenylmethoxy) alkylamines would belong to the second group of antispasmodics, which are strong bases, having pKa larger than 8, and act as cation on smooth muscle of ileum. Larger variability of the thermodynamic activity of these compounds might perhaps depend on the facts that they irreversibly inhibit the motility of smooth muscles, that the free bases easily decompose in aqueous solution, and that the preparation of saturated solution of the bases is very difficult.The smooth muscles of uterus would be similar to small intestines rather than to tracheal muscles from the mode of action of several antispasmodics and the ω-(diphenylmethoxy) alkylamines." @default.
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- W2605427859 date "1961-01-01" @default.
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- W2605427859 title "Chemicopharmacological Studies on Antispasmodic Action. XIX" @default.
- W2605427859 doi "https://doi.org/10.1248/yakushi1947.81.5_693" @default.
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