FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605432898> ?p ?o ?g. }

• W2605432898 endingPage "885" @default.
• W2605432898 startingPage "877" @default.
• W2605432898 abstract "Despite the recent explosive rise in number of genetic markers for complex disease traits identified in genome-wide association studies, there is still a large gap between the known heritability of these traits and the part explained by these markers. To gauge whether this ‘heritability gap’ is closing, we first identified genome-wide significant SNPs from the literature and performed replication analyses for 32 highly relevant traits from five broad disease areas in 13 436 subjects of the Lifelines Cohort. Next, we calculated the variance explained by multi-SNP genetic risk scores (GRSs) for each trait, and compared it to their broad- and narrow-sense heritabilities captured by all common SNPs. The majority of all previously-associated SNPs (median=75%) were significantly associated with their respective traits. All GRSs were significant, with unweighted GRSs generally explaining less phenotypic variance than weighted GRSs, for which the explained variance was highest for height (15.5%) and varied between 0.02 and 6.7% for the other traits. Broad-sense common-SNP heritability estimates were significant for all traits, with the additive effect of common SNPs explaining 48.9% of the variance for height and between 5.6 and 39.2% for the other traits. Dominance effects were uniformly small (0–1.5%) and not significant. On average, the variance explained by the weighted GRSs accounted for only 10.7% of the common-SNP heritability of the 32 traits. These results indicate that GRSs may not yet be ready for accurate personalized prediction of complex disease traits limiting widespread adoption in clinical practice." @default.
• W2605432898 created "2017-04-28" @default.
• W2605432898 creator A5009609107 @default.
• W2605432898 creator A5009803531 @default.
• W2605432898 creator A5010367070 @default.
• W2605432898 creator A5018149893 @default.
• W2605432898 creator A5027571680 @default.
• W2605432898 creator A5030603878 @default.
• W2605432898 creator A5035504682 @default.
• W2605432898 creator A5042352129 @default.
• W2605432898 creator A5049240208 @default.
• W2605432898 creator A5052333223 @default.
• W2605432898 creator A5052368642 @default.
• W2605432898 creator A5060728967 @default.
• W2605432898 creator A5066704276 @default.
• W2605432898 creator A5088404253 @default.
• W2605432898 creator A5089879675 @default.
• W2605432898 creator A5090566985 @default.
• W2605432898 date "2017-04-12" @default.
• W2605432898 modified "2023-10-09" @default.
• W2605432898 title "Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study" @default.
• W2605432898 cites W1705993293 @default.
• W2605432898 cites W1744127096 @default.
• W2605432898 cites W1855058198 @default.
• W2605432898 cites W1971141173 @default.
• W2605432898 cites W1992436001 @default.
• W2605432898 cites W1992911777 @default.
• W2605432898 cites W2005421391 @default.
• W2605432898 cites W2006561549 @default.
• W2605432898 cites W2007669329 @default.
• W2605432898 cites W2022100988 @default.
• W2605432898 cites W2027837618 @default.
• W2605432898 cites W2033151532 @default.
• W2605432898 cites W2039153962 @default.
• W2605432898 cites W2047783882 @default.
• W2605432898 cites W2058401000 @default.
• W2605432898 cites W2059542829 @default.
• W2605432898 cites W2066192569 @default.
• W2605432898 cites W2080235308 @default.
• W2605432898 cites W2093369971 @default.
• W2605432898 cites W2099598799 @default.
• W2605432898 cites W2100532651 @default.
• W2605432898 cites W2101605059 @default.
• W2605432898 cites W2102984318 @default.
• W2605432898 cites W2103516623 @default.
• W2605432898 cites W2107916366 @default.
• W2605432898 cites W2108525019 @default.
• W2605432898 cites W2109625917 @default.
• W2605432898 cites W2110808585 @default.
• W2605432898 cites W2114452675 @default.
• W2605432898 cites W2116868464 @default.
• W2605432898 cites W2117362890 @default.
• W2605432898 cites W2117446594 @default.
• W2605432898 cites W2118669458 @default.
• W2605432898 cites W2126237420 @default.
• W2605432898 cites W2126773823 @default.
• W2605432898 cites W2135528729 @default.
• W2605432898 cites W2135895196 @default.
• W2605432898 cites W2137216147 @default.
• W2605432898 cites W2139852278 @default.
• W2605432898 cites W2142323439 @default.
• W2605432898 cites W2143286837 @default.
• W2605432898 cites W2145474755 @default.
• W2605432898 cites W2147452548 @default.
• W2605432898 cites W2153118028 @default.
• W2605432898 cites W2155496693 @default.
• W2605432898 cites W2155766871 @default.
• W2605432898 cites W2159422401 @default.
• W2605432898 cites W2161633633 @default.
• W2605432898 cites W2163924952 @default.
• W2605432898 cites W2164468497 @default.
• W2605432898 cites W2169863448 @default.
• W2605432898 cites W2188707104 @default.
• W2605432898 cites W2411709723 @default.
• W2605432898 cites W2480095902 @default.
• W2605432898 doi "https://doi.org/10.1038/ejhg.2017.50" @default.
• W2605432898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5520063" @default.
• W2605432898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28401901" @default.
• W2605432898 hasPublicationYear "2017" @default.
• W2605432898 type Work @default.
• W2605432898 sameAs 2605432898 @default.
• W2605432898 citedByCount "59" @default.
• W2605432898 countsByYear W26054328982017 @default.
• W2605432898 countsByYear W26054328982018 @default.
• W2605432898 countsByYear W26054328982019 @default.
• W2605432898 countsByYear W26054328982020 @default.
• W2605432898 countsByYear W26054328982021 @default.
• W2605432898 countsByYear W26054328982022 @default.
• W2605432898 countsByYear W26054328982023 @default.
• W2605432898 crossrefType "journal-article" @default.
• W2605432898 hasAuthorship W2605432898A5009609107 @default.
• W2605432898 hasAuthorship W2605432898A5009803531 @default.
• W2605432898 hasAuthorship W2605432898A5010367070 @default.
• W2605432898 hasAuthorship W2605432898A5018149893 @default.
• W2605432898 hasAuthorship W2605432898A5027571680 @default.
• W2605432898 hasAuthorship W2605432898A5030603878 @default.
• W2605432898 hasAuthorship W2605432898A5035504682 @default.
• W2605432898 hasAuthorship W2605432898A5042352129 @default.

• next