Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605434590> ?p ?o ?g. }
- W2605434590 endingPage "5321" @default.
- W2605434590 startingPage "5317" @default.
- W2605434590 abstract "One long-standing issue in directed C-H functionalization is that either nitrogen or sulfur atoms present in heterocyclic substrates may bind preferentially to a transition-metal catalyst rather than to the desired directing group. This competitive binding has largely hindered the application of C-H functionalization in late-stage heterocycle drug discovery. Reported here is the use of an oxazoline-based directing group capable of overriding the poisoning effect of a wide range of heterocycle substrates. The potential use of this directing group in pharmaceutical drug discovery is illustrated by diversification of Telmisartan (an antagonist for the angiotensin II receptor) through copper-mediated C-H amination, hydroxylation, thiolation, arylation, and trifluoromethylation." @default.
- W2605434590 created "2017-04-28" @default.
- W2605434590 creator A5001670924 @default.
- W2605434590 creator A5018115355 @default.
- W2605434590 creator A5061790176 @default.
- W2605434590 creator A5080816898 @default.
- W2605434590 creator A5090467265 @default.
- W2605434590 creator A5054278070 @default.
- W2605434590 date "2017-04-10" @default.
- W2605434590 modified "2023-10-11" @default.
- W2605434590 title "Copper‐Mediated Late‐Stage Functionalization of Heterocycle‐Containing Molecules" @default.
- W2605434590 cites W1969487950 @default.
- W2605434590 cites W1969676465 @default.
- W2605434590 cites W1975237431 @default.
- W2605434590 cites W1988080642 @default.
- W2605434590 cites W1993793186 @default.
- W2605434590 cites W2008582837 @default.
- W2605434590 cites W2032735202 @default.
- W2605434590 cites W2044353456 @default.
- W2605434590 cites W2050791488 @default.
- W2605434590 cites W2055580127 @default.
- W2605434590 cites W2080854581 @default.
- W2605434590 cites W2081421786 @default.
- W2605434590 cites W2089571021 @default.
- W2605434590 cites W2092328284 @default.
- W2605434590 cites W2093433408 @default.
- W2605434590 cites W2109598544 @default.
- W2605434590 cites W2120208258 @default.
- W2605434590 cites W2123331492 @default.
- W2605434590 cites W2128782637 @default.
- W2605434590 cites W2128969383 @default.
- W2605434590 cites W2129697991 @default.
- W2605434590 cites W2129936280 @default.
- W2605434590 cites W2258983844 @default.
- W2605434590 cites W2294170112 @default.
- W2605434590 cites W2299327344 @default.
- W2605434590 cites W2301259650 @default.
- W2605434590 cites W2302106194 @default.
- W2605434590 cites W2314245876 @default.
- W2605434590 cites W2316245510 @default.
- W2605434590 cites W2318230067 @default.
- W2605434590 cites W2326309772 @default.
- W2605434590 cites W2328762096 @default.
- W2605434590 cites W2328935951 @default.
- W2605434590 cites W2407040666 @default.
- W2605434590 cites W2489366484 @default.
- W2605434590 cites W2916862177 @default.
- W2605434590 cites W3213613663 @default.
- W2605434590 cites W4235575516 @default.
- W2605434590 cites W4238152247 @default.
- W2605434590 cites W4240839403 @default.
- W2605434590 cites W4252171031 @default.
- W2605434590 doi "https://doi.org/10.1002/anie.201611287" @default.
- W2605434590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28393446" @default.
- W2605434590 hasPublicationYear "2017" @default.
- W2605434590 type Work @default.
- W2605434590 sameAs 2605434590 @default.
- W2605434590 citedByCount "74" @default.
- W2605434590 countsByYear W26054345902017 @default.
- W2605434590 countsByYear W26054345902018 @default.
- W2605434590 countsByYear W26054345902019 @default.
- W2605434590 countsByYear W26054345902020 @default.
- W2605434590 countsByYear W26054345902021 @default.
- W2605434590 countsByYear W26054345902022 @default.
- W2605434590 countsByYear W26054345902023 @default.
- W2605434590 crossrefType "journal-article" @default.
- W2605434590 hasAuthorship W2605434590A5001670924 @default.
- W2605434590 hasAuthorship W2605434590A5018115355 @default.
- W2605434590 hasAuthorship W2605434590A5054278070 @default.
- W2605434590 hasAuthorship W2605434590A5061790176 @default.
- W2605434590 hasAuthorship W2605434590A5080816898 @default.
- W2605434590 hasAuthorship W2605434590A5090467265 @default.
- W2605434590 hasBestOaLocation W26054345901 @default.
- W2605434590 hasConcept C115537861 @default.
- W2605434590 hasConcept C147789679 @default.
- W2605434590 hasConcept C161790260 @default.
- W2605434590 hasConcept C178790620 @default.
- W2605434590 hasConcept C181199279 @default.
- W2605434590 hasConcept C185592680 @default.
- W2605434590 hasConcept C198503264 @default.
- W2605434590 hasConcept C21951064 @default.
- W2605434590 hasConcept C2775944816 @default.
- W2605434590 hasConcept C2781109383 @default.
- W2605434590 hasConcept C32909587 @default.
- W2605434590 hasConcept C55493867 @default.
- W2605434590 hasConcept C74187038 @default.
- W2605434590 hasConceptScore W2605434590C115537861 @default.
- W2605434590 hasConceptScore W2605434590C147789679 @default.
- W2605434590 hasConceptScore W2605434590C161790260 @default.
- W2605434590 hasConceptScore W2605434590C178790620 @default.
- W2605434590 hasConceptScore W2605434590C181199279 @default.
- W2605434590 hasConceptScore W2605434590C185592680 @default.
- W2605434590 hasConceptScore W2605434590C198503264 @default.
- W2605434590 hasConceptScore W2605434590C21951064 @default.
- W2605434590 hasConceptScore W2605434590C2775944816 @default.
- W2605434590 hasConceptScore W2605434590C2781109383 @default.
- W2605434590 hasConceptScore W2605434590C32909587 @default.
- W2605434590 hasConceptScore W2605434590C55493867 @default.