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• W2605462644 abstract "The emergence of antibiotic resistance has resulted in an increasing difficulty treating clinical infections associated with biofilms formation, one of the key processes contributed to enhance antibiotic resistance in return. With the rapid development of nanotechnology, a new way to overcome antibiotic resistance was opened up. Based on multiple properties especially antibacterial potential of MoS2 nanosheets that have aroused wide attention, herein, a novel antimicrobial agent to combat resistant gram-positive Staphylococcus aureus (S. aureus) and gram-negative Salmonella was prepared using chitosan functionalized MoS2 nanosheets loading tetracycline hydrochloride drugs (abbreviated to CM-TH). The antibacterial and anti-biofilm activities of CM-TH nanocomposites expressed a synergy effect that the combination of nanomaterials and antibiotics were more efficient than both alone did. Particularly, the MIC values were generally decreased by a factor of dozens, suggesting CM-TH may become a possible alternative to traditional antibiotics in disrupting the biofilms and further to overcome antibiotic resistance in treating medical diseases." @default.
• W2605462644 created "2017-04-28" @default.
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• W2605462644 date "2017-05-08" @default.
• W2605462644 modified "2023-09-25" @default.
• W2605462644 title "Antibiotic-loaded MoS₂nanosheets to combat bacterial resistance via biofilm inhibition" @default.
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• W2605462644 doi "https://doi.org/10.1088/1361-6528/aa6c9b" @default.
• W2605462644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28480869" @default.
• W2605462644 hasPublicationYear "2017" @default.
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