FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605474906> ?p ?o ?g. }

• W2605474906 endingPage "584" @default.
• W2605474906 startingPage "574" @default.
• W2605474906 abstract "Insulin signaling in the brain has been implicated in the control of satiety, glucose homeostasis and energy balance. However, insulin signaling is dispensable in energy homeostasis controlling AgRP or POMC neurons and it is unclear which other neurons regulate these effects. Here we describe an ancient insulin/NPY neuronal network that governs energy homeostasis across phyla. To address the role of insulin action specifically in NPY neurons, we generated a variety of models by selectively removing insulin signaling in NPY neurons in flies and mice and testing the consequences on energy homeostasis. By specifically targeting the insulin receptor in both fly and mouse NPY expressing neurons, we found NPY-specific insulin signaling controls food intake and energy expenditure, and lack of insulin signaling in NPY neurons leads to increased energy stores and an obese phenotype. Additionally, the lack of insulin signaling in NPY neurons leads to a dysregulation of GH/IGF-1 axis and to altered insulin sensitivity. Taken together, these results suggest that insulin actions in NPY neurons is critical for maintaining energy balance and an impairment of this pathway may be causally linked to the development of metabolic diseases." @default.
• W2605474906 created "2017-04-28" @default.
• W2605474906 creator A5000737891 @default.
• W2605474906 creator A5003634687 @default.
• W2605474906 creator A5025786453 @default.
• W2605474906 creator A5026199229 @default.
• W2605474906 creator A5028862826 @default.
• W2605474906 creator A5029220305 @default.
• W2605474906 creator A5063814387 @default.
• W2605474906 creator A5064425126 @default.
• W2605474906 creator A5071798264 @default.
• W2605474906 creator A5074667950 @default.
• W2605474906 creator A5080863114 @default.
• W2605474906 creator A5087855721 @default.
• W2605474906 creator A5087998130 @default.
• W2605474906 creator A5088384506 @default.
• W2605474906 date "2017-06-01" @default.
• W2605474906 modified "2023-10-09" @default.
• W2605474906 title "Insulin controls food intake and energy balance via NPY neurons" @default.
• W2605474906 cites W1499189927 @default.
• W2605474906 cites W1893713587 @default.
• W2605474906 cites W1970225575 @default.
• W2605474906 cites W1973483415 @default.
• W2605474906 cites W1975233843 @default.
• W2605474906 cites W1978010345 @default.
• W2605474906 cites W1981415589 @default.
• W2605474906 cites W1992431456 @default.
• W2605474906 cites W2002941555 @default.
• W2605474906 cites W2003544616 @default.
• W2605474906 cites W2005943019 @default.
• W2605474906 cites W2009872845 @default.
• W2605474906 cites W2014887370 @default.
• W2605474906 cites W2016508574 @default.
• W2605474906 cites W2021506444 @default.
• W2605474906 cites W2037226098 @default.
• W2605474906 cites W2038066118 @default.
• W2605474906 cites W2049009766 @default.
• W2605474906 cites W2052985185 @default.
• W2605474906 cites W2055646225 @default.
• W2605474906 cites W2060802533 @default.
• W2605474906 cites W2072556905 @default.
• W2605474906 cites W2077524078 @default.
• W2605474906 cites W2077545686 @default.
• W2605474906 cites W2079503496 @default.
• W2605474906 cites W2085184474 @default.
• W2605474906 cites W2087333588 @default.
• W2605474906 cites W2088777766 @default.
• W2605474906 cites W2099542131 @default.
• W2605474906 cites W2112743857 @default.
• W2605474906 cites W2124653803 @default.
• W2605474906 cites W2125183883 @default.
• W2605474906 cites W2125354005 @default.
• W2605474906 cites W2126796697 @default.
• W2605474906 cites W2157247104 @default.
• W2605474906 cites W2157765869 @default.
• W2605474906 cites W2164402702 @default.
• W2605474906 cites W2168414233 @default.
• W2605474906 cites W2170021091 @default.
• W2605474906 cites W2216761824 @default.
• W2605474906 cites W2307093368 @default.
• W2605474906 cites W2586421092 @default.
• W2605474906 cites W284944624 @default.
• W2605474906 cites W4205488307 @default.
• W2605474906 cites W4241277272 @default.
• W2605474906 doi "https://doi.org/10.1016/j.molmet.2017.03.013" @default.
• W2605474906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5444095" @default.
• W2605474906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28580287" @default.
• W2605474906 hasPublicationYear "2017" @default.
• W2605474906 type Work @default.
• W2605474906 sameAs 2605474906 @default.
• W2605474906 citedByCount "105" @default.
• W2605474906 countsByYear W26054749062017 @default.
• W2605474906 countsByYear W26054749062018 @default.
• W2605474906 countsByYear W26054749062019 @default.
• W2605474906 countsByYear W26054749062020 @default.
• W2605474906 countsByYear W26054749062021 @default.
• W2605474906 countsByYear W26054749062022 @default.
• W2605474906 countsByYear W26054749062023 @default.
• W2605474906 crossrefType "journal-article" @default.
• W2605474906 hasAuthorship W2605474906A5000737891 @default.
• W2605474906 hasAuthorship W2605474906A5003634687 @default.
• W2605474906 hasAuthorship W2605474906A5025786453 @default.
• W2605474906 hasAuthorship W2605474906A5026199229 @default.
• W2605474906 hasAuthorship W2605474906A5028862826 @default.
• W2605474906 hasAuthorship W2605474906A5029220305 @default.
• W2605474906 hasAuthorship W2605474906A5063814387 @default.
• W2605474906 hasAuthorship W2605474906A5064425126 @default.
• W2605474906 hasAuthorship W2605474906A5071798264 @default.
• W2605474906 hasAuthorship W2605474906A5074667950 @default.
• W2605474906 hasAuthorship W2605474906A5080863114 @default.
• W2605474906 hasAuthorship W2605474906A5087855721 @default.
• W2605474906 hasAuthorship W2605474906A5087998130 @default.
• W2605474906 hasAuthorship W2605474906A5088384506 @default.
• W2605474906 hasBestOaLocation W26054749061 @default.
• W2605474906 hasConcept C112446052 @default.
• W2605474906 hasConcept C118303440 @default.
• W2605474906 hasConcept C126322002 @default.
• W2605474906 hasConcept C134018914 @default.

• next