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- W2605479912 abstract "Drug receptor in smooth muscles was examined with vascular strips from a guinea pig, chiefly using irreversible antagonists, and following facts were revealed.1) The vascular smooth muscles showed the following phenomena:(a) 2-Haloalkylamines showed irreversible antagonism against adrenaline and tolazoline are protective against this irreversible inhibition but not cysteine. From this result site of action of 2-haloalkylamines is assumed to be the adrenergic receptor. These 2-haloalkylamines showed irreversible antagonism against barium chloride and histamine in about 100 times higher concentration than against adrenaline. Application of a high concentration of barium chloride and 2-haloalkylamines at the same time results in protection against contractive action of barium chloride. This fact suggests that there is a specific receptors for histamine and barium chloride besides the adrenergic receptor in the vascular smooth muscles taking part in the mechanism of muscle contraction.(b) SH-Inhibitors also showed irreversible antagonism against adrenaline, while adrenaline had no protective action against this phenomenon due to its change by heavy metals. Phenylephrine, tolazoline, and cysteine had protective action against this irreversible inhibition. This fact suggests that the site of action of SH inhibitors is the adrenergic receptor, especially its SH group.2) The foregoing facts suggest that the receptor in the vascular smooth muscles has an SH group, which binds with heavy metals and is protected by cysteine, and a functional group which binds with 2-haloalkylamine and is not protected by cysteine." @default.
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- W2605479912 date "1962-01-01" @default.
- W2605479912 modified "2023-10-05" @default.
- W2605479912 title "Studies on Drug Receptors of Smooth Muscle. VI" @default.
- W2605479912 doi "https://doi.org/10.1248/yakushi1947.82.1_14" @default.
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