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• W2605482562 startingPage "7" @default.
• W2605482562 abstract "Metabolic and signaling pathways are integrated to determine T cell fate and function. As stimulated T cells gain distinct effector functions, specific metabolic programs and demands are also adopted. These changes are essential for T cell effector function, and alterations or dysregulation of metabolic pathways can modulate T cell function. One physiological setting that impacts T cell metabolism is the tumor microenvironment. The metabolism of cancer cells themselves can limit nutrients and accumulate waste products. In addition to the expression of inhibitory ligands that directly modify T cell physiology, T cell metabolism may be strongly inhibited in the tumor microenvironment. This suppression of T cell metabolism may inhibit effector T cell activity while promoting suppressive regulatory T cells, and act as a barrier to effective immunotherapies. A thorough understanding of the effect of the tumor microenvironment on the immune system will support the continued improvement of immune based therapies for cancer patients." @default.
• W2605482562 created "2017-04-28" @default.
• W2605482562 creator A5028839251 @default.
• W2605482562 creator A5056373193 @default.
• W2605482562 creator A5074208252 @default.
• W2605482562 date "2017-06-01" @default.
• W2605482562 modified "2023-10-18" @default.
• W2605482562 title "Dysfunctional T cell metabolism in the tumor microenvironment" @default.
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• W2605482562 doi "https://doi.org/10.1016/j.cytogfr.2017.04.003" @default.
• W2605482562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5710836" @default.

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