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- W2605485144 abstract "Development of a protective and broadly-acting vaccine against the most widely distributed human malaria parasite, Plasmodium vivax, will be a major step towards malaria elimination. However, a P. vivax vaccine has remained elusive by the scarcity of pre-clinical models to test protective efficacy and support further clinical trials. In this study, we report the development of a highly protective CSP-based P. vivax vaccine, a virus-like particle (VLP) known as Rv21, able to provide 100% sterile protection against a stringent sporozoite challenge in rodent models to malaria, where IgG2a antibodies were associated with protection in absence of detectable PvCSP-specific T cell responses. Additionally, we generated two novel transgenic rodent P. berghei parasite lines, where the P. berghei csp gene coding sequence has been replaced with either full-length P. vivax VK210 or the allelic VK247 csp that additionally express GFP-Luciferase. Efficacy of Rv21 surpassed viral-vectored vaccination using ChAd63 and MVA. We show for the first time that a chimeric VK210/247 antigen can elicit high level cross-protection against parasites expressing either CSP allele, which provide accessible and affordable models suitable to support the development of P. vivax vaccines candidates. Rv21 is progressing to GMP production and has entered a path towards clinical evaluation." @default.
- W2605485144 created "2017-04-28" @default.
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- W2605485144 date "2017-04-18" @default.
- W2605485144 modified "2023-10-14" @default.
- W2605485144 title "Rational development of a protective P. vivax vaccine evaluated with transgenic rodent parasite challenge models" @default.
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- W2605485144 cites W1993957287 @default.
- W2605485144 cites W1995801354 @default.
- W2605485144 cites W1995866374 @default.
- W2605485144 cites W1996494698 @default.
- W2605485144 cites W2002288384 @default.
- W2605485144 cites W2002856830 @default.
- W2605485144 cites W2004972574 @default.
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- W2605485144 cites W2073800141 @default.
- W2605485144 cites W2080034876 @default.
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- W2605485144 doi "https://doi.org/10.1038/srep46482" @default.
- W2605485144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5394459" @default.
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- W2605485144 hasPublicationYear "2017" @default.
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