FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605571538> ?p ?o ?g. }

• W2605571538 endingPage "4079" @default.
• W2605571538 startingPage "4072" @default.
• W2605571538 abstract "A previous study has confirmed that the central melanocortin system was able to mediate skeletal muscle AMP-activated protein kinase (AMPK) activation in mice fed a high-fat diet, while activation of the AMPK signaling pathway significantly induced mitochondrial biogenesis. Our hypothesis was that melanocortin 4 receptor (MC4R) was involved in the development of skeletal muscle injury in diabetic rats. In this study, we treated diabetic rats intracerebroventricularly with MC4R agonist R027-3225 or antagonist SHU9119, respectively. Then, we measured the production of reactive oxygen species (ROS), the levels of malondialdehyde (MDA) and glutathione (GSH), the mitochondrial DNA (mtDNA) content and mitochondrial biogenesis, and the protein levels of p-AMPK, AMPK, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and manganese superoxide dismutase (MnSOD) in the skeletal muscle of diabetic rats. The results showed that there was significant skeletal muscle injury in the diabetic rats along with serious oxidative stress and decreased mitochondrial biogenesis. Treatment with R027-3225 reduced oxidative stress and induced mitochondrial biogenesis in skeletal muscle, and also activated the AMPK-SIRT1-PGC-1α signaling pathway. However, diabetic rats injected with MC4R antagonist SHU9119 showed an aggravated oxidative stress and mitochondrial dysfunction in skeletal muscle. In conclusion, our results revealed that MC4R activation was able to attenuate oxidative stress and mitochondrial dysfunction in skeletal muscle induced by diabetes partially through activating the AMPK-SIRT1-PGC-1α signaling pathway. J. Cell. Biochem. 118: 4072-4079, 2017. © 2017 Wiley Periodicals, Inc." @default.
• W2605571538 created "2017-04-28" @default.
• W2605571538 creator A5012394995 @default.
• W2605571538 creator A5020240685 @default.
• W2605571538 creator A5047200703 @default.
• W2605571538 creator A5060097766 @default.
• W2605571538 creator A5060844635 @default.
• W2605571538 creator A5063627915 @default.
• W2605571538 creator A5067617942 @default.
• W2605571538 creator A5084927002 @default.
• W2605571538 creator A5086247223 @default.
• W2605571538 creator A5089936834 @default.
• W2605571538 creator A5091407415 @default.
• W2605571538 date "2017-06-22" @default.
• W2605571538 modified "2023-10-17" @default.
• W2605571538 title "Melanocortin 4 Receptor Activation Attenuates Mitochondrial Dysfunction in Skeletal Muscle of Diabetic Rats" @default.
• W2605571538 cites W1592304792 @default.
• W2605571538 cites W1964876127 @default.
• W2605571538 cites W1971082641 @default.
• W2605571538 cites W1975546990 @default.
• W2605571538 cites W1981025527 @default.
• W2605571538 cites W1990886132 @default.
• W2605571538 cites W1999114565 @default.
• W2605571538 cites W2000870007 @default.
• W2605571538 cites W2022267544 @default.
• W2605571538 cites W2025639892 @default.
• W2605571538 cites W2038510532 @default.
• W2605571538 cites W2045948521 @default.
• W2605571538 cites W2047265080 @default.
• W2605571538 cites W2051884493 @default.
• W2605571538 cites W2058232819 @default.
• W2605571538 cites W2058768220 @default.
• W2605571538 cites W2067298061 @default.
• W2605571538 cites W2071631797 @default.
• W2605571538 cites W2075403303 @default.
• W2605571538 cites W2077834313 @default.
• W2605571538 cites W2079134421 @default.
• W2605571538 cites W2092769218 @default.
• W2605571538 cites W2101489273 @default.
• W2605571538 cites W2111648449 @default.
• W2605571538 cites W2114725982 @default.
• W2605571538 cites W2119657969 @default.
• W2605571538 cites W2123016403 @default.
• W2605571538 cites W2128557475 @default.
• W2605571538 cites W2146594526 @default.
• W2605571538 cites W2152101492 @default.
• W2605571538 cites W2177426766 @default.
• W2605571538 cites W2277742836 @default.
• W2605571538 cites W2335218893 @default.
• W2605571538 cites W2417061833 @default.
• W2605571538 doi "https://doi.org/10.1002/jcb.26062" @default.
• W2605571538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28409883" @default.
• W2605571538 hasPublicationYear "2017" @default.
• W2605571538 type Work @default.
• W2605571538 sameAs 2605571538 @default.
• W2605571538 citedByCount "5" @default.
• W2605571538 countsByYear W26055715382018 @default.
• W2605571538 countsByYear W26055715382020 @default.
• W2605571538 countsByYear W26055715382021 @default.
• W2605571538 countsByYear W26055715382023 @default.
• W2605571538 crossrefType "journal-article" @default.
• W2605571538 hasAuthorship W2605571538A5012394995 @default.
• W2605571538 hasAuthorship W2605571538A5020240685 @default.
• W2605571538 hasAuthorship W2605571538A5047200703 @default.
• W2605571538 hasAuthorship W2605571538A5060097766 @default.
• W2605571538 hasAuthorship W2605571538A5060844635 @default.
• W2605571538 hasAuthorship W2605571538A5063627915 @default.
• W2605571538 hasAuthorship W2605571538A5067617942 @default.
• W2605571538 hasAuthorship W2605571538A5084927002 @default.
• W2605571538 hasAuthorship W2605571538A5086247223 @default.
• W2605571538 hasAuthorship W2605571538A5089936834 @default.
• W2605571538 hasAuthorship W2605571538A5091407415 @default.
• W2605571538 hasConcept C104317684 @default.
• W2605571538 hasConcept C11960822 @default.
• W2605571538 hasConcept C126322002 @default.
• W2605571538 hasConcept C127561419 @default.
• W2605571538 hasConcept C134018914 @default.
• W2605571538 hasConcept C185592680 @default.
• W2605571538 hasConcept C2776151105 @default.
• W2605571538 hasConcept C2776536020 @default.
• W2605571538 hasConcept C2776780712 @default.
• W2605571538 hasConcept C2777229759 @default.
• W2605571538 hasConcept C2779959927 @default.
• W2605571538 hasConcept C2779993316 @default.
• W2605571538 hasConcept C2780124434 @default.
• W2605571538 hasConcept C28859421 @default.
• W2605571538 hasConcept C55493867 @default.
• W2605571538 hasConcept C71315377 @default.
• W2605571538 hasConcept C71924100 @default.
• W2605571538 hasConcept C86803240 @default.
• W2605571538 hasConcept C95444343 @default.
• W2605571538 hasConcept C97029542 @default.
• W2605571538 hasConceptScore W2605571538C104317684 @default.
• W2605571538 hasConceptScore W2605571538C11960822 @default.
• W2605571538 hasConceptScore W2605571538C126322002 @default.
• W2605571538 hasConceptScore W2605571538C127561419 @default.
• W2605571538 hasConceptScore W2605571538C134018914 @default.
• W2605571538 hasConceptScore W2605571538C185592680 @default.

• next