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- W2605607640 abstract "1. Culture medium conditioned by endothelial cells contained anticoagulant activity. The concentrated serum-free conditioned medium, not only directly inhibited Factor Xa activity but also enhanced the inactivation of Xa activity by antithrombin III. Acidic glycosaminoglycans (GAGs) isolated from conditioned culture medium showed Xa inhibition only in the presence of antithrombin III.2. On the cultured endothelial cell monolayer, thrombin activity was inhibited by antithrombin III. This inhibitory effect was absent on the endothelial cells pre-treated with F. heparinum enzyme.These results suggest that GAGs (probably heparan sulfate) on the endothelial cells exert heparin-like activity both in the liquid phase after secretion and in the solid phase on the cell surface." @default.
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- W2605607640 date "1984-01-01" @default.
- W2605607640 modified "2023-10-04" @default.
- W2605607640 title "Anticoagulant Activity of Endothelial Cells" @default.
- W2605607640 doi "https://doi.org/10.5551/jat1973.12.4_767" @default.
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