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- W2605610378 abstract "The effects of nifedipine on intimal thickenning and cell proliferation in the aorta were studied. Cannulation of catheter from femoral artery to abdominal aorta in rabbits and rats, caused intimal thickenning. Administration of nifedipine to rats prevented the DNA increment in cannulated aorta. Explanted smooth muscle cell from intimal thickenning in rabbit aorta proliferated more rapidly than those from the media. The proliferation was suppressed by the addition of nifedipine in vitro. The addition of nifedipine to smooth muscle cell inhibited acyl CoA cholesterol acyl transferase, synthesis of cholesterol from acetate. These results suggested that nifedipine prevented the intimal thickenning by inhibiting proliferation of proliferative intimal cell and cholesterol ester synthesis from acetate in smooth muscle cell." @default.
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- W2605610378 date "1987-01-01" @default.
- W2605610378 modified "2023-10-17" @default.
- W2605610378 title "Effect of Nifedipine on Intimal Thickenning and Cell Proliferation of Aorta" @default.
- W2605610378 doi "https://doi.org/10.5551/jat1973.15.1_179" @default.
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