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- W2605612010 abstract "It has not been well established the effect of clofibrate on glucose tolerance and its glucoselowering mechanism in non-insulin dependent diabetes mellitus (NIDDM).We studied, therefore, the effect of 4 weeks clofibrate treatment on glucose tolerance together with its glucose-lowering mechanism in 15 NIDDM patients. Long-term effect of clofibrate on glucose tolerance was also followed for 7 months in 37 NIDDM patients. All patients were treated with ordered diet and/or exercise before and during the administration of clofibrate, 1500mg daily after every meals, and the studies were started after the establishment of the constant body weight and plasma glucose levels. 75g oral glucose tolerance test (75g OGTT) and insulin tolerance test (ITT) were carried out before and at 4 weeks of the treatment.1) Fasting plasma glucose values were 168.1±9.5mg/dl and 136.5±6.0mg/dl (p<0.01) before and at 4 weeks of clofibrate, respectively. Plasma glucose values during 75g OGTT showed significant decrease in each point (p<0.01), especially at the latter points, and ∑ glucose was decreased by 20.6±2.3% after the clofibrate treatment. Fasting IRI levels and IRI responses were also decreased statistically.2) However, insulinogenic index and ∑ IRI/∑ glucose ratio during 75g OGTT were not changed by the treatment. Enhanced glucose fall was observed in ITT. On the other hand, correlation was not observed between the decrease of FFA, triglyceride and total cholesterol levels, and the improved glucose tolerance.3) Glucose-lowering effect was continued during the administration periods of 7 months, and its effect was statistically significant with the same glucose-lowering rate observed in the 4 weeks administration study.These results suggest that clofibrate would improve the glucose tolerance in NIDDM, and the glucose-lowering mechanism might be derived from the enhanced tissue sensitivity to insulin." @default.
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- W2605612010 date "1984-01-01" @default.
- W2605612010 modified "2023-10-16" @default.
- W2605612010 title "Glucose-lowering Mechanism of Clofibrate and its Long-term Effect on Glucose Tolerance in Non-Insulin Dependent Diabetes Mellitus" @default.
- W2605612010 doi "https://doi.org/10.5551/jat1973.11.6_1335" @default.
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