FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605622183> ?p ?o ?g. }

• W2605622183 abstract "Autophagy, the processes of delivery of intracellular components to lysosomes, regulates induction of inflammation. Inducible macroautophagy degrades inflammasomes and dysfunctional mitochondria to downregulate inflammatory signals. Nonetheless, the effects of constitutive basal autophagy on inflammatory signals are largely unknown. Here, we report a previously unknown effect of basal autophagy. Lysosomal inhibition induced weak inflammatory signals in the absence of a cellular stimulus and in the presence of a nutrient supply, and their induction was impaired by MyD88 deficiency. During lysosomal inhibition, MyD88 was accumulated, and overabundant MyD88 autoactivated downstream signaling or enhanced TLR/IL-1R-mediated signaling. MyD88 is probably degraded via basal microautophagy because macroautophagy inhibitors, ATG5 deficiency, and an activator of chaperone-mediated autophagy did not affect MyD88. Analysis using a chimeric protein whose monomerization/dimerization can be switched revealed that monomeric MyD88 is susceptible to degradation. Immunoprecipitation of monomeric MyD88 revealed its interaction with TRAF6. In TRAF6-deficient cells, degradation of basal MyD88 was enhanced, suggesting that TRAF6 participates in protection from basal autophagy. Thus, basal autophagy lowers monomeric MyD88 expression, and thereby autoactivation of inflammatory signals is prevented. Given that impairment of lysosomes occurs in various settings, our results provide novel insights into the etiology of inflammatory signals that affect consequences of inflammation." @default.
• W2605622183 created "2017-04-28" @default.
• W2605622183 creator A5014119193 @default.
• W2605622183 creator A5016492251 @default.
• W2605622183 creator A5036792590 @default.
• W2605622183 creator A5038725297 @default.
• W2605622183 creator A5058632940 @default.
• W2605622183 creator A5081483210 @default.
• W2605622183 creator A5082018968 @default.
• W2605622183 date "2017-04-21" @default.
• W2605622183 modified "2023-10-11" @default.
• W2605622183 title "Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88" @default.
• W2605622183 cites W1581857504 @default.
• W2605622183 cites W1586362463 @default.
• W2605622183 cites W1699784618 @default.
• W2605622183 cites W1884934928 @default.
• W2605622183 cites W1964033480 @default.
• W2605622183 cites W1966625479 @default.
• W2605622183 cites W1967311822 @default.
• W2605622183 cites W1985124617 @default.
• W2605622183 cites W1987769185 @default.
• W2605622183 cites W1991105254 @default.
• W2605622183 cites W1992659717 @default.
• W2605622183 cites W1998585620 @default.
• W2605622183 cites W2001045944 @default.
• W2605622183 cites W2001158499 @default.
• W2605622183 cites W2017593971 @default.
• W2605622183 cites W2020466729 @default.
• W2605622183 cites W2021043148 @default.
• W2605622183 cites W2021919397 @default.
• W2605622183 cites W2022964430 @default.
• W2605622183 cites W2026622074 @default.
• W2605622183 cites W2028536701 @default.
• W2605622183 cites W2037454778 @default.
• W2605622183 cites W2038554653 @default.
• W2605622183 cites W2042433863 @default.
• W2605622183 cites W2042767581 @default.
• W2605622183 cites W2042851093 @default.
• W2605622183 cites W2043823247 @default.
• W2605622183 cites W2048030072 @default.
• W2605622183 cites W2049412582 @default.
• W2605622183 cites W2061866569 @default.
• W2605622183 cites W2064741210 @default.
• W2605622183 cites W2066697766 @default.
• W2605622183 cites W2070500204 @default.
• W2605622183 cites W2074517544 @default.
• W2605622183 cites W2091489434 @default.
• W2605622183 cites W2092751085 @default.
• W2605622183 cites W2103339779 @default.
• W2605622183 cites W2109491705 @default.
• W2605622183 cites W2111342035 @default.
• W2605622183 cites W2111922856 @default.
• W2605622183 cites W2113010696 @default.
• W2605622183 cites W2117738774 @default.
• W2605622183 cites W2118968734 @default.
• W2605622183 cites W2124043033 @default.
• W2605622183 cites W2129121329 @default.
• W2605622183 cites W2134192973 @default.
• W2605622183 cites W2139462909 @default.
• W2605622183 cites W2148281700 @default.
• W2605622183 cites W2153328565 @default.
• W2605622183 cites W2157551652 @default.
• W2605622183 cites W2161150914 @default.
• W2605622183 cites W2164778558 @default.
• W2605622183 cites W2169904105 @default.
• W2605622183 cites W2201316930 @default.
• W2605622183 cites W2205249281 @default.
• W2605622183 cites W2218210464 @default.
• W2605622183 cites W2294238922 @default.
• W2605622183 cites W2304287990 @default.
• W2605622183 cites W2541855063 @default.
• W2605622183 cites W2752326209 @default.
• W2605622183 doi "https://doi.org/10.1038/s41598-017-01246-w" @default.
• W2605622183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5430896" @default.
• W2605622183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28432355" @default.
• W2605622183 hasPublicationYear "2017" @default.
• W2605622183 type Work @default.
• W2605622183 sameAs 2605622183 @default.
• W2605622183 citedByCount "20" @default.
• W2605622183 countsByYear W26056221832018 @default.
• W2605622183 countsByYear W26056221832019 @default.
• W2605622183 countsByYear W26056221832020 @default.
• W2605622183 countsByYear W26056221832021 @default.
• W2605622183 countsByYear W26056221832022 @default.
• W2605622183 countsByYear W26056221832023 @default.
• W2605622183 crossrefType "journal-article" @default.
• W2605622183 hasAuthorship W2605622183A5014119193 @default.
• W2605622183 hasAuthorship W2605622183A5016492251 @default.
• W2605622183 hasAuthorship W2605622183A5036792590 @default.
• W2605622183 hasAuthorship W2605622183A5038725297 @default.
• W2605622183 hasAuthorship W2605622183A5058632940 @default.
• W2605622183 hasAuthorship W2605622183A5081483210 @default.
• W2605622183 hasAuthorship W2605622183A5082018968 @default.
• W2605622183 hasBestOaLocation W26056221831 @default.
• W2605622183 hasConcept C134018914 @default.
• W2605622183 hasConcept C164027704 @default.
• W2605622183 hasConcept C185592680 @default.
• W2605622183 hasConcept C190283241 @default.
• W2605622183 hasConcept C203014093 @default.
• W2605622183 hasConcept C203522944 @default.

• next