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• W2605641522 startingPage "e1005490" @default.
• W2605641522 abstract "Cells use surface receptors to estimate concentrations of external ligands. Limits on the accuracy of such estimations have been well studied for pairs of ligand and receptor species. However, the environment typically contains many ligands, which can bind to the same receptors with different affinities, resulting in cross-talk. In traditional rate models, such cross-talk prevents accurate inference of concentrations of individual ligands. In contrast, here we show that knowing the precise timing sequence of stochastic binding and unbinding events allows one receptor to provide information about multiple ligands simultaneously and with a high accuracy. We show that such high-accuracy estimation of multiple concentrations can be realized with simple structural modifications of the familiar kinetic proofreading biochemical network diagram. We give two specific examples of such modifications. We argue that structural and functional features of real cellular biochemical sensory networks in immune cells, such as feedforward and feedback loops or ligand antagonism, sometimes can be understood as solutions to the accurate multi-ligand estimation problem." @default.
• W2605641522 created "2017-04-28" @default.
• W2605641522 creator A5045298784 @default.
• W2605641522 creator A5071388278 @default.
• W2605641522 date "2017-04-14" @default.
• W2605641522 modified "2023-10-12" @default.
• W2605641522 title "Simple biochemical networks allow accurate sensing of multiple ligands with a single receptor" @default.
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• W2605641522 doi "https://doi.org/10.1371/journal.pcbi.1005490" @default.
• W2605641522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5409536" @default.
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• W2605641522 hasPublicationYear "2017" @default.
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