Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605645355> ?p ?o ?g. }
- W2605645355 endingPage "463" @default.
- W2605645355 startingPage "456" @default.
- W2605645355 abstract "Thrombocytopenia is an important cause of hemorrhage and death after radiation injury, but the pathogenesis of radiation-induced thrombocytopenia has not been fully characterized. Here, we investigated the influence of radiation-induced endothelial cell injury on platelet regeneration. We found that human umbilical vein endothelial cells (HUVECs) underwent a high rate of apoptosis, accompanied by a significant reduction in the expression of vascular endothelial growth factor (VEGF) at 96 h after radiation. Subsequent investigations revealed that radiation injury lowered the ability of HUVECs to attract migrating megakaryocytes (MKs). Moreover, the adhesion of MKs to HUVECs was markedly reduced when HUVECs were exposed to radiation, accompanied by a decreased production of platelets by MKs. In vivo study showed that VEGF treatment significantly promoted the migration of MKs into the vascular niche and accelerated platelet recovery in irradiated mice. Our studies demonstrate that endothelial cell injury contributes to the slow recovery of platelets after radiation, which provides a deeper insight into the pathogenesis of thrombocytopenia induced by radiation." @default.
- W2605645355 created "2017-04-28" @default.
- W2605645355 creator A5001629068 @default.
- W2605645355 creator A5003377806 @default.
- W2605645355 creator A5020588158 @default.
- W2605645355 creator A5030123331 @default.
- W2605645355 creator A5039976696 @default.
- W2605645355 creator A5040931420 @default.
- W2605645355 creator A5043858190 @default.
- W2605645355 creator A5051364953 @default.
- W2605645355 creator A5056522759 @default.
- W2605645355 creator A5060037184 @default.
- W2605645355 creator A5064363137 @default.
- W2605645355 creator A5087161473 @default.
- W2605645355 date "2017-04-11" @default.
- W2605645355 modified "2023-10-16" @default.
- W2605645355 title "Effect of radiation-induced endothelial cell injury on platelet regeneration by megakaryocytes" @default.
- W2605645355 cites W1857401588 @default.
- W2605645355 cites W1861988602 @default.
- W2605645355 cites W1864920229 @default.
- W2605645355 cites W190110694 @default.
- W2605645355 cites W1964048327 @default.
- W2605645355 cites W1965779501 @default.
- W2605645355 cites W1968493854 @default.
- W2605645355 cites W1976954262 @default.
- W2605645355 cites W1988547391 @default.
- W2605645355 cites W1993232218 @default.
- W2605645355 cites W2006016016 @default.
- W2605645355 cites W2019057640 @default.
- W2605645355 cites W2031955647 @default.
- W2605645355 cites W2045652632 @default.
- W2605645355 cites W2057074686 @default.
- W2605645355 cites W2065412503 @default.
- W2605645355 cites W2077129452 @default.
- W2605645355 cites W2080274993 @default.
- W2605645355 cites W2084117610 @default.
- W2605645355 cites W2097320562 @default.
- W2605645355 cites W2097466377 @default.
- W2605645355 cites W2103486381 @default.
- W2605645355 cites W2121337426 @default.
- W2605645355 cites W2137498530 @default.
- W2605645355 cites W214380766 @default.
- W2605645355 cites W2150650800 @default.
- W2605645355 cites W2153503145 @default.
- W2605645355 cites W2157091913 @default.
- W2605645355 cites W2337117424 @default.
- W2605645355 cites W2346103630 @default.
- W2605645355 cites W2465201573 @default.
- W2605645355 cites W2519796374 @default.
- W2605645355 cites W4247933942 @default.
- W2605645355 cites W600195407 @default.
- W2605645355 doi "https://doi.org/10.1093/jrr/rrx015" @default.
- W2605645355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5570070" @default.
- W2605645355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28402443" @default.
- W2605645355 hasPublicationYear "2017" @default.
- W2605645355 type Work @default.
- W2605645355 sameAs 2605645355 @default.
- W2605645355 citedByCount "8" @default.
- W2605645355 countsByYear W26056453552018 @default.
- W2605645355 countsByYear W26056453552019 @default.
- W2605645355 countsByYear W26056453552020 @default.
- W2605645355 countsByYear W26056453552021 @default.
- W2605645355 countsByYear W26056453552022 @default.
- W2605645355 crossrefType "journal-article" @default.
- W2605645355 hasAuthorship W2605645355A5001629068 @default.
- W2605645355 hasAuthorship W2605645355A5003377806 @default.
- W2605645355 hasAuthorship W2605645355A5020588158 @default.
- W2605645355 hasAuthorship W2605645355A5030123331 @default.
- W2605645355 hasAuthorship W2605645355A5039976696 @default.
- W2605645355 hasAuthorship W2605645355A5040931420 @default.
- W2605645355 hasAuthorship W2605645355A5043858190 @default.
- W2605645355 hasAuthorship W2605645355A5051364953 @default.
- W2605645355 hasAuthorship W2605645355A5056522759 @default.
- W2605645355 hasAuthorship W2605645355A5060037184 @default.
- W2605645355 hasAuthorship W2605645355A5064363137 @default.
- W2605645355 hasAuthorship W2605645355A5087161473 @default.
- W2605645355 hasBestOaLocation W26056453551 @default.
- W2605645355 hasConcept C123012128 @default.
- W2605645355 hasConcept C167734588 @default.
- W2605645355 hasConcept C171056886 @default.
- W2605645355 hasConcept C185592680 @default.
- W2605645355 hasConcept C190283241 @default.
- W2605645355 hasConcept C202751555 @default.
- W2605645355 hasConcept C203014093 @default.
- W2605645355 hasConcept C2777025900 @default.
- W2605645355 hasConcept C2777411675 @default.
- W2605645355 hasConcept C2780942790 @default.
- W2605645355 hasConcept C502942594 @default.
- W2605645355 hasConcept C55493867 @default.
- W2605645355 hasConcept C71924100 @default.
- W2605645355 hasConcept C86803240 @default.
- W2605645355 hasConcept C89560881 @default.
- W2605645355 hasConcept C95444343 @default.
- W2605645355 hasConceptScore W2605645355C123012128 @default.
- W2605645355 hasConceptScore W2605645355C167734588 @default.
- W2605645355 hasConceptScore W2605645355C171056886 @default.
- W2605645355 hasConceptScore W2605645355C185592680 @default.
- W2605645355 hasConceptScore W2605645355C190283241 @default.