FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605666075> ?p ?o ?g. }

• W2605666075 endingPage "40593" @default.
• W2605666075 startingPage "40583" @default.
• W2605666075 abstract "// Sheng Dong 1 , Xiang Ma 1 , Zusen Wang 1 , Bing Han 1 , Hao Zou 1 , Zehua Wu 1 , Yunjin Zang 2 and Likun Zhuang 2 1 Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China 2 Institute of Transplantation Science, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China Correspondence to: Likun Zhuang, email: zlk0823@163.com Yunjin Zang, email: zangyunjin12@163.com Keywords: YY1, HDAC1, HDAC inhibitor, HCC, drug sensitivity Received: February 20, 2017      Accepted: April 05, 2017      Published: April 18, 2017 ABSTRACT YY1 is a DNA-binding transcription factor and reported to be involved in cancer progression. Histone deacetylase inhibitor (HDACi) could inhibit proliferation and promote apoptosis of Hepatocellular carcinoma (HCC) cells. However, it is unclear about the roles of YY1 in the sensitivity of HCC cells to HDACi. In this study, firstly, we identified two drug-response profiles to HDACi in HCC cell lines, while our results showed that HDAC1 expression was positively correlated with YY1 in HCC cell lines and primary tumor tissues. Secondly, YY1 decreased the sensitivity of HCC cells to HDACi in vitro and in vivo . Furthermore, we found that YY1 promoted HDAC1 expression by binding to its promoter, while HDAC1 in turn up-regulated the expression of YY1. In conclusion, our results showed that YY1 could reduce the sensitivity of HCC cells to HDACi and might be a potential therapeutic target in HCC." @default.
• W2605666075 created "2017-04-28" @default.
• W2605666075 creator A5008154695 @default.
• W2605666075 creator A5009742409 @default.
• W2605666075 creator A5012890681 @default.
• W2605666075 creator A5025219580 @default.
• W2605666075 creator A5033856964 @default.
• W2605666075 creator A5070837465 @default.
• W2605666075 creator A5076182073 @default.
• W2605666075 creator A5086485866 @default.
• W2605666075 date "2017-04-18" @default.
• W2605666075 modified "2023-10-16" @default.
• W2605666075 title "YY1 promotes HDAC1 expression and decreases sensitivity of hepatocellular carcinoma cells to HDAC inhibitor" @default.
• W2605666075 cites W1972149587 @default.
• W2605666075 cites W1974741877 @default.
• W2605666075 cites W1999836732 @default.
• W2605666075 cites W2006382865 @default.
• W2605666075 cites W2015407907 @default.
• W2605666075 cites W2047660391 @default.
• W2605666075 cites W2053420149 @default.
• W2605666075 cites W2056022574 @default.
• W2605666075 cites W2057753203 @default.
• W2605666075 cites W2082496903 @default.
• W2605666075 cites W2099803844 @default.
• W2605666075 cites W2136121675 @default.
• W2605666075 cites W2142558595 @default.
• W2605666075 cites W2152379507 @default.
• W2605666075 cites W2157391786 @default.
• W2605666075 cites W2164380111 @default.
• W2605666075 cites W2166156797 @default.
• W2605666075 cites W2168607453 @default.
• W2605666075 cites W2169510176 @default.
• W2605666075 cites W2170249039 @default.
• W2605666075 cites W2229860828 @default.
• W2605666075 cites W2258249404 @default.
• W2605666075 cites W2312913993 @default.
• W2605666075 cites W2342245373 @default.
• W2605666075 cites W2342868230 @default.
• W2605666075 cites W2463909130 @default.
• W2605666075 cites W2520809168 @default.
• W2605666075 cites W2538451045 @default.
• W2605666075 doi "https://doi.org/10.18632/oncotarget.17196" @default.
• W2605666075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5522268" @default.
• W2605666075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28489564" @default.
• W2605666075 hasPublicationYear "2017" @default.
• W2605666075 type Work @default.
• W2605666075 sameAs 2605666075 @default.
• W2605666075 citedByCount "20" @default.
• W2605666075 countsByYear W26056660752017 @default.
• W2605666075 countsByYear W26056660752018 @default.
• W2605666075 countsByYear W26056660752019 @default.
• W2605666075 countsByYear W26056660752020 @default.
• W2605666075 countsByYear W26056660752021 @default.
• W2605666075 countsByYear W26056660752022 @default.
• W2605666075 countsByYear W26056660752023 @default.
• W2605666075 crossrefType "journal-article" @default.
• W2605666075 hasAuthorship W2605666075A5008154695 @default.
• W2605666075 hasAuthorship W2605666075A5009742409 @default.
• W2605666075 hasAuthorship W2605666075A5012890681 @default.
• W2605666075 hasAuthorship W2605666075A5025219580 @default.
• W2605666075 hasAuthorship W2605666075A5033856964 @default.
• W2605666075 hasAuthorship W2605666075A5070837465 @default.
• W2605666075 hasAuthorship W2605666075A5076182073 @default.
• W2605666075 hasAuthorship W2605666075A5086485866 @default.
• W2605666075 hasBestOaLocation W26056660751 @default.
• W2605666075 hasConcept C101762097 @default.
• W2605666075 hasConcept C104317684 @default.
• W2605666075 hasConcept C150194340 @default.
• W2605666075 hasConcept C190283241 @default.
• W2605666075 hasConcept C2776202225 @default.
• W2605666075 hasConcept C2778019345 @default.
• W2605666075 hasConcept C2778305200 @default.
• W2605666075 hasConcept C502942594 @default.
• W2605666075 hasConcept C54355233 @default.
• W2605666075 hasConcept C62944979 @default.
• W2605666075 hasConcept C64927066 @default.
• W2605666075 hasConcept C71924100 @default.
• W2605666075 hasConcept C81885089 @default.
• W2605666075 hasConcept C85240754 @default.
• W2605666075 hasConcept C86803240 @default.
• W2605666075 hasConceptScore W2605666075C101762097 @default.
• W2605666075 hasConceptScore W2605666075C104317684 @default.
• W2605666075 hasConceptScore W2605666075C150194340 @default.
• W2605666075 hasConceptScore W2605666075C190283241 @default.
• W2605666075 hasConceptScore W2605666075C2776202225 @default.
• W2605666075 hasConceptScore W2605666075C2778019345 @default.
• W2605666075 hasConceptScore W2605666075C2778305200 @default.
• W2605666075 hasConceptScore W2605666075C502942594 @default.
• W2605666075 hasConceptScore W2605666075C54355233 @default.
• W2605666075 hasConceptScore W2605666075C62944979 @default.
• W2605666075 hasConceptScore W2605666075C64927066 @default.
• W2605666075 hasConceptScore W2605666075C71924100 @default.
• W2605666075 hasConceptScore W2605666075C81885089 @default.
• W2605666075 hasConceptScore W2605666075C85240754 @default.
• W2605666075 hasConceptScore W2605666075C86803240 @default.
• W2605666075 hasIssue "25" @default.
• W2605666075 hasLocation W26056660751 @default.
• W2605666075 hasLocation W26056660752 @default.

• next