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• W2605706554 endingPage "832" @default.
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• W2605706554 abstract "Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in Agouti-Related Peptide (AgRP) neurons of the hypothalamus. We recently reported that neuron-specific deletion of GHS-R completely prevents diet-induced obesity (DIO) in mice by activating non-shivering thermogenesis. To further decipher the specific neuronal circuits mediating the metabolic effects of GHS-R, we generated AgRP neuron-specific GHS-R knockout mice (AgRP-Cre;Ghsrf/f). Our data showed that GHS-R in AgRP neurons is required for ghrelin’s stimulatory effects on growth hormone secretion, acute food intake and adiposity, but not for long-term total food intake. Importantly, deletion of GHS-R in AgRP neurons attenuated diet-induced obesity (DIO) and enhanced cold-resistance in mice fed high fat diet (HFD). The HFD-fed knockout mice showed increased energy expenditure, and exhibited enhanced thermogenic activation in both brown and subcutaneous fat; this implies that GHS-R suppression in AgRP neurons enhances sympathetic outflow. In summary, our results suggest that AgRP neurons are key site for GHS-R mediated thermogenesis, and demonstrate that GHS-R in AgRP neurons plays crucial roles in governing energy utilization and pathogenesis of DIO." @default.
• W2605706554 created "2017-04-28" @default.
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• W2605706554 date "2017-04-14" @default.
• W2605706554 modified "2023-10-17" @default.
• W2605706554 title "Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis" @default.
• W2605706554 cites W1437291867 @default.
• W2605706554 cites W1499189927 @default.
• W2605706554 cites W1592119877 @default.
• W2605706554 cites W1616806865 @default.
• W2605706554 cites W1637971961 @default.
• W2605706554 cites W1947875006 @default.
• W2605706554 cites W1981102645 @default.
• W2605706554 cites W1981415589 @default.
• W2605706554 cites W1983714777 @default.
• W2605706554 cites W1986168431 @default.
• W2605706554 cites W1988803699 @default.
• W2605706554 cites W1990095603 @default.
• W2605706554 cites W1990218993 @default.
• W2605706554 cites W1995734405 @default.
• W2605706554 cites W1997437691 @default.
• W2605706554 cites W1999248363 @default.
• W2605706554 cites W2001077637 @default.
• W2605706554 cites W2002941555 @default.
• W2605706554 cites W2003967044 @default.
• W2605706554 cites W2008646871 @default.
• W2605706554 cites W2010759952 @default.
• W2605706554 cites W2011437674 @default.
• W2605706554 cites W2015174242 @default.
• W2605706554 cites W2019455536 @default.
• W2605706554 cites W2020843850 @default.
• W2605706554 cites W2022614975 @default.
• W2605706554 cites W2026821456 @default.
• W2605706554 cites W2032668395 @default.
• W2605706554 cites W2035600501 @default.
• W2605706554 cites W2037464735 @default.
• W2605706554 cites W2047128756 @default.
• W2605706554 cites W2048053645 @default.
• W2605706554 cites W2048505107 @default.
• W2605706554 cites W2050859306 @default.
• W2605706554 cites W2061999440 @default.
• W2605706554 cites W2069302715 @default.
• W2605706554 cites W2076262535 @default.
• W2605706554 cites W2083560906 @default.
• W2605706554 cites W2085372550 @default.
• W2605706554 cites W2096017323 @default.
• W2605706554 cites W2097643786 @default.
• W2605706554 cites W2101782891 @default.
• W2605706554 cites W2103533003 @default.
• W2605706554 cites W2106488251 @default.
• W2605706554 cites W2108365604 @default.
• W2605706554 cites W2111033628 @default.
• W2605706554 cites W2111734250 @default.
• W2605706554 cites W2119649463 @default.
• W2605706554 cites W2120079420 @default.
• W2605706554 cites W2122289503 @default.
• W2605706554 cites W2122767257 @default.
• W2605706554 cites W2127818104 @default.
• W2605706554 cites W2130893755 @default.
• W2605706554 cites W2132358997 @default.
• W2605706554 cites W2139359479 @default.
• W2605706554 cites W2139789471 @default.
• W2605706554 cites W2140530719 @default.
• W2605706554 cites W2140691623 @default.
• W2605706554 cites W2143711558 @default.
• W2605706554 cites W2144489715 @default.
• W2605706554 cites W2149079606 @default.
• W2605706554 cites W2157319851 @default.
• W2605706554 cites W2159444491 @default.
• W2605706554 cites W2159664830 @default.
• W2605706554 cites W2161418574 @default.
• W2605706554 cites W2163865122 @default.
• W2605706554 cites W2170874580 @default.
• W2605706554 cites W2171804530 @default.
• W2605706554 cites W2171909092 @default.
• W2605706554 cites W2263406908 @default.
• W2605706554 cites W2359450119 @default.
• W2605706554 cites W4211061743 @default.
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• W2605706554 doi "https://doi.org/10.3390/ijms18040832" @default.
• W2605706554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5412416" @default.
• W2605706554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28420089" @default.
• W2605706554 hasPublicationYear "2017" @default.
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• W2605706554 citedByCount "38" @default.

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