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- W2605707029 abstract "Pazopanib is a tyrosine kinase receptor antagonist used for renal cell carcinoma and soft tissue sarcoma that inhibits tumour growth and angiogenesis. A common side effect of pazopanib is hypertension. We report a case of a 69-year-old woman with clear cell renal cell carcinoma who developed a large right occipital intracerebral haemorrhage 3 weeks after initiating pazopanib. Although this was initially suspected to be a haemorrhagic metastasis, MRI revealed bi-occipital oedema, supporting a diagnosis of posterior reversible encephalopathy syndrome (PRES). A craniectomy was required. Immunohistochemical stains for renal cell carcinoma antigen, CA IX and PAX8 were negative. This case suggests that PRES and intracerebral haemorrhage may result from pazopanib use and are important complications to consider prior to initiating this agent." @default.
- W2605707029 created "2017-04-28" @default.
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- W2605707029 date "2017-04-17" @default.
- W2605707029 modified "2023-09-25" @default.
- W2605707029 title "Pazopanib-associated posterior reversible encephalopathy syndrome with intracerebral haemorrhage" @default.
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- W2605707029 doi "https://doi.org/10.1136/bcr-2016-218221" @default.
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