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- W2605766014 endingPage "64533" @default.
- W2605766014 startingPage "64520" @default.
- W2605766014 abstract "Chronic kidney disease (CKD) is increasingly being accepted as a type of renal ageing. The kidney undergoes age-related alterations in both structure and function. To date, a comprehensive analysis of cellular senescence and senescence-associated secretory phenotype (SASP) in CKD is lacking. Hence, this review mainly discusses the relationship between the two phenomena to show the striking similarities between SASP and CKD-associated secretory phenotype (CASP). It has been reported that replicative senescence, stress-induced premature ageing, and epigenetic abnormalities participate in the occurrence and development of CKD. Genomic damage and external environmental stimuli cause increased levels of oxidative stress and a chronic inflammatory state as a result of irreversible cell cycle arrest and low doses of SASP. Similar to SASP, CASP factors activate tissue repair by multiple mechanisms. Once tissue repair fails, the accumulated SASP or CASP species aggravate DNA damage response (DDR) and cause the senescent cells to secrete more SASP factors, accelerating the process of cellular ageing and eventually leading to various ageing-related changes. It is concluded that cellular senescence and SASP participate in the pathological process of CKD, and correspondingly CKD accelerated the progression of cell senescence and the secretion of SASP. These results will facilitate the integration of these mechanisms into the care and management of CKD and other age-related diseases." @default.
- W2605766014 created "2017-04-28" @default.
- W2605766014 creator A5006792547 @default.
- W2605766014 creator A5060135800 @default.
- W2605766014 creator A5065987768 @default.
- W2605766014 date "2017-04-21" @default.
- W2605766014 modified "2023-10-11" @default.
- W2605766014 title "Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease" @default.
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