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• W2605781488 abstract "Hybridization-based methods for the detection of nucleic acid sequences are important in research and medicine. Short probes provide sequence specificity, but do not always provide a durable signal. Sequence-specific covalent crosslink formation can anchor probes to target DNA and might also provide an additional layer of target selectivity. Here, we developed a new crosslinking reaction for the covalent capture of specific nucleic acid sequences. This process involved reaction of an abasic (Ap) site in a probe strand with an adenine residue in the target strand and was used for the detection of a disease-relevant T→A mutation at position 1799 of the human BRAF kinase gene sequence. Ap-containing probes were easily prepared and displayed excellent specificity for the mutant sequence under isothermal assay conditions. It was further shown that nanopore technology provides a high contrast—in essence, digital—signal that enables sensitive, single-molecule sensing of the cross-linked duplexes." @default.
• W2605781488 created "2017-04-28" @default.
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• W2605781488 date "2017-05-26" @default.
• W2605781488 modified "2023-10-03" @default.
• W2605781488 title "Sequence-Specific Covalent Capture Coupled with High-Contrast Nanopore Detection of a Disease-Derived Nucleic Acid Sequence" @default.
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• W2605781488 doi "https://doi.org/10.1002/cbic.201700204" @default.
• W2605781488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139021" @default.
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• W2605781488 hasPublicationYear "2017" @default.
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