FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605803181> ?p ?o ?g. }

• W2605803181 endingPage "250" @default.
• W2605803181 startingPage "242" @default.
• W2605803181 abstract "To investigate the effect of resolvin D1 (RvD1) on the Nod-like receptor family pyrin domain-containing (NLRP3) inflammasome and the nuclear factor-kappa beta (NF-κB) pathway in streptozotocin (STZ)-induced diabetic retinopathy in rats.Ninety-six male rats were divided into four groups: control, STZ, RvD1, and vehicle. The rats with diabetic retinopathy induced by STZ in the RvD1 and vehicle groups were given an intravitreal injection of RvD1 (1,000 ng/kg) or the same dosage of vehicle, respectively. All rats were euthanized 7 days following treatment. Hematoxylin and eosin staining was used to observe the pathological changes in the retinal tissues. The location and expression of the NLRP3 inflammasome components, including NLRP3, caspase-associated recruitment domain (ASC), and caspase-1, in the retinas were detected using immunohistochemistry, real-time PCR, and western blot, respectively. Retinal homogenate of rats were collected for the detection of the downstream molecules interleukin 1 beta (IL-1β) and IL-18 of the NLRP3 inflammasome with enzyme-linked immunosorbent assay kits.The levels of NLRP3, ASC, cleaved caspase-1, IL-1β, and IL-18 were upregulated in the retinas of the STZ-induced diabetic rats; however, these changes were partially inhibited by the RvD1 treatment. Furthermore, the administration of RvD1 suppressed activation of NF-kB, which was upregulated in STZ-induced diabetic retinopathy.RvD1 plays a protective role in STZ-induced diabetic retinopathy by inhibiting the level of activation of the NLRP3 inflammasome and associated cytokine production, suggesting targeting of this pathway might be an effective strategy in treatment of diabetic retinopathy." @default.
• W2605803181 created "2017-04-28" @default.
• W2605803181 creator A5023083950 @default.
• W2605803181 creator A5054709496 @default.
• W2605803181 creator A5066341763 @default.
• W2605803181 creator A5076112088 @default.
• W2605803181 creator A5084854649 @default.
• W2605803181 date "2017-01-01" @default.
• W2605803181 modified "2023-10-16" @default.
• W2605803181 title "Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway." @default.
• W2605803181 cites W1529674879 @default.
• W2605803181 cites W1530493878 @default.
• W2605803181 cites W1963780604 @default.
• W2605803181 cites W1972483153 @default.
• W2605803181 cites W1977781630 @default.
• W2605803181 cites W2000537420 @default.
• W2605803181 cites W2001614846 @default.
• W2605803181 cites W2007973129 @default.
• W2605803181 cites W2009004909 @default.
• W2605803181 cites W2009800174 @default.
• W2605803181 cites W2025449580 @default.
• W2605803181 cites W2031740343 @default.
• W2605803181 cites W2033450092 @default.
• W2605803181 cites W2042363066 @default.
• W2605803181 cites W2046127225 @default.
• W2605803181 cites W2047640394 @default.
• W2605803181 cites W2050449334 @default.
• W2605803181 cites W2074324837 @default.
• W2605803181 cites W2084333601 @default.
• W2605803181 cites W2092460415 @default.
• W2605803181 cites W2099020618 @default.
• W2605803181 cites W2103010344 @default.
• W2605803181 cites W2116459455 @default.
• W2605803181 cites W2129685307 @default.
• W2605803181 cites W2132949972 @default.
• W2605803181 cites W2138480916 @default.
• W2605803181 cites W2147870526 @default.
• W2605803181 cites W2171212614 @default.
• W2605803181 cites W2258118187 @default.
• W2605803181 cites W2547643921 @default.
• W2605803181 cites W4211205882 @default.
• W2605803181 cites W4211217520 @default.
• W2605803181 cites W569434376 @default.
• W2605803181 cites W616913137 @default.
• W2605803181 cites W761234068 @default.
• W2605803181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5398882" @default.
• W2605803181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28465656" @default.
• W2605803181 hasPublicationYear "2017" @default.
• W2605803181 type Work @default.
• W2605803181 sameAs 2605803181 @default.
• W2605803181 citedByCount "37" @default.
• W2605803181 countsByYear W26058031812017 @default.
• W2605803181 countsByYear W26058031812018 @default.
• W2605803181 countsByYear W26058031812019 @default.
• W2605803181 countsByYear W26058031812020 @default.
• W2605803181 countsByYear W26058031812021 @default.
• W2605803181 countsByYear W26058031812022 @default.
• W2605803181 countsByYear W26058031812023 @default.
• W2605803181 crossrefType "journal-article" @default.
• W2605803181 hasAuthorship W2605803181A5023083950 @default.
• W2605803181 hasAuthorship W2605803181A5054709496 @default.
• W2605803181 hasAuthorship W2605803181A5066341763 @default.
• W2605803181 hasAuthorship W2605803181A5076112088 @default.
• W2605803181 hasAuthorship W2605803181A5084854649 @default.
• W2605803181 hasConcept C104317684 @default.
• W2605803181 hasConcept C118487528 @default.
• W2605803181 hasConcept C123298856 @default.
• W2605803181 hasConcept C126322002 @default.
• W2605803181 hasConcept C127561419 @default.
• W2605803181 hasConcept C134018914 @default.
• W2605803181 hasConcept C139174496 @default.
• W2605803181 hasConcept C139964883 @default.
• W2605803181 hasConcept C185592680 @default.
• W2605803181 hasConcept C2776415932 @default.
• W2605803181 hasConcept C2776914184 @default.
• W2605803181 hasConcept C2777209026 @default.
• W2605803181 hasConcept C2779280383 @default.
• W2605803181 hasConcept C2779829184 @default.
• W2605803181 hasConcept C2780827179 @default.
• W2605803181 hasConcept C55493867 @default.
• W2605803181 hasConcept C555293320 @default.
• W2605803181 hasConcept C71924100 @default.
• W2605803181 hasConcept C86339819 @default.
• W2605803181 hasConceptScore W2605803181C104317684 @default.
• W2605803181 hasConceptScore W2605803181C118487528 @default.
• W2605803181 hasConceptScore W2605803181C123298856 @default.
• W2605803181 hasConceptScore W2605803181C126322002 @default.
• W2605803181 hasConceptScore W2605803181C127561419 @default.
• W2605803181 hasConceptScore W2605803181C134018914 @default.
• W2605803181 hasConceptScore W2605803181C139174496 @default.
• W2605803181 hasConceptScore W2605803181C139964883 @default.
• W2605803181 hasConceptScore W2605803181C185592680 @default.
• W2605803181 hasConceptScore W2605803181C2776415932 @default.
• W2605803181 hasConceptScore W2605803181C2776914184 @default.
• W2605803181 hasConceptScore W2605803181C2777209026 @default.
• W2605803181 hasConceptScore W2605803181C2779280383 @default.
• W2605803181 hasConceptScore W2605803181C2779829184 @default.
• W2605803181 hasConceptScore W2605803181C2780827179 @default.

• next