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- W2605858339 endingPage "1136" @default.
- W2605858339 startingPage "1121" @default.
- W2605858339 abstract "Despite its importance in regulating emotion and mental wellbeing, the complex structure and function of the serotonergic system present formidable challenges toward understanding its mechanisms. In this paper, we review studies investigating the interactions between serotonergic and related brain systems and their behavior at multiple scales, with a focus on biologically-based computational modeling. We first discuss serotonergic intracellular signaling and neuronal excitability, followed by neuronal circuit and systems levels. At each level of organization, we will discuss the experimental work accompanied by related computational modeling work. We then suggest that a multiscale modeling approach that integrates the various levels of neurobiological organization could potentially transform the way we understand the complex functions associated with serotonin." @default.
- W2605858339 created "2017-04-28" @default.
- W2605858339 creator A5005224008 @default.
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- W2605858339 creator A5056387400 @default.
- W2605858339 creator A5059817221 @default.
- W2605858339 date "2017-04-18" @default.
- W2605858339 modified "2023-10-16" @default.
- W2605858339 title "Toward a multiscale modeling framework for understanding serotonergic function" @default.
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