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- W2605900479 abstract "Every year, melanoma causes nearly 10,000 deaths in the United States yet alarmingly most cases can be preventable (U.S. Department of Health and Human Services, 2013). Ulceration has been identified as a poor prognostic factor for melanoma and is associated with decreased survival time. This study aims to identify risk factors and host factors associated with ulceration. We used the GEM study, a population-based study of 3,579 individuals to evaluate ulcerated tumors and associated risk factor. After evaluating demographic, phenotypic, histological, behavioral, and clinical variables in relation to ulceration, there were significant correlations between ulceration and Breslow thickness (P < 0.0001), nodular histology (P < 0.0001), the presence of mitosis (P < 0.0001), solar elastosis (P=0.01), and subjects who tan poorly (P=0.03). We found no associations between any measures of sun exposure and ulceration. As an individual’s ability to tan and the development solar elastosis are significantly associated with ulceration, it may be that genetic factors influence the development of ulcerated melanoma and should be further explored." @default.
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- W2605900479 date "2017-05-01" @default.
- W2605900479 modified "2023-09-26" @default.
- W2605900479 title "785 Predictors of ulceration in melanoma" @default.
- W2605900479 doi "https://doi.org/10.1016/j.jid.2017.02.810" @default.
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