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- W2605907986 abstract "(Immunity 37, 813–826; November 16, 2012) In the “Extended Discussion” of the Supplemental Information (page 4), the authors described that they used two lines of Wnt reporter mice and found that malignant transformation of TCF-1-deficient early thymocytes did not lead to activation of the reporter genes. They were recently notified that a wrong strain was distributed to them as the second reporter TOP-EGFP strain. The use of this erroneous strain does not affect any of the conclusions drawn in the article; however, any comments related to the TOP-EGFP strain should be omitted in that paragraph. This error has now been corrected in the Supplemental Information online. The authors apologize for the error and any inconvenience that might have resulted. The TCF-1 and LEF-1 Transcription Factors Have Cooperative and Opposing Roles in T Cell Development and MalignancyYu et al.ImmunityOctober 25, 2012In BriefThe TCF-1 and LEF-1 transcription factors are known to play critical roles in normal thymocyte development. Unexpectedly, we found that TCF-1-deficient (Tcf7−/−) mice developed aggressive T cell malignancy, resembling human T cell acute lymphoblastic leukemia (T-ALL). LEF-1 was aberrantly upregulated in premalignant Tcf7−/− early thymocytes and lymphoma cells. We further demonstrated that TCF-1 directly repressed LEF-1 expression in early thymocytes and that conditional inactivation of Lef1 greatly delayed or prevented T cell malignancy in Tcf7−/− mice. Full-Text PDF Open Archive" @default.
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- W2605907986 date "2014-01-01" @default.
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- W2605907986 title "The TCF-1 and LEF-1 Transcription Factors Have Cooperative and Opposing Roles in T Cell Development and Malignancy" @default.
- W2605907986 doi "https://doi.org/10.1016/j.immuni.2013.12.001" @default.
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