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- W2605913400 abstract "FFA is a cicatricial alopecia that affects the frontotemporal hairline with or without eyebrows, body hair, glabellar red dots (GRD) and facial papules (FP). D-OCT non-invasively images tissue in real-time cross-sectional and en face views up to 2 mm below skin surface and captures blood vessel distribution. In order to describe structural and vascular findings in FFA using D-OCT, 5 patients with FFA were imaged on cicatricial alopecic band, inflammatory hairline, eyebrow, uninvolved scalp, GRD, FP and involved arm skin. This was repeated in 3 healthy individuals as controls. Epidermal thickness: control (0.8mm), active inflammatory hairline (0.13mm) cicatricial skin (0.7mm). On initial inflammatory stages, collagen distribution is irregular and in advanced cicatricial stages, a concentric hyperreflectant “onion-shape “ pattern is observed. There is a direct proportional relationship between clinical fibrosis and loss of the superior granular vascular plexus. This relationship is inverted in the deeper plexus, where there is a perifollicular “crown-like” distribution and perforating vasculature communicates both plexuses. In FP, vessels invaginate within the dome shaped structures and are surrounded by concentric “onion-shape” collagen bundles. GRD are formed by conglomerated vessels that surround follicular openings. Both are encircled by a “crown” of vessels. Arms had loss of the normal criss-cross superficial pattern. Epidermal thickness is increased in inflammatory and decreased in cicatricial skin. There is compensatory neovascularization probably due to tissue ischemia. FP and GRD have a vascular and inflammatory component. OCT is a powerful non-invasive tool that can help diagnose and monitor activity of FFA and may help to elucidate the complex physiopathology of the disease." @default.
- W2605913400 created "2017-04-28" @default.
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- W2605913400 date "2017-05-01" @default.
- W2605913400 modified "2023-09-23" @default.
- W2605913400 title "861 Frontal fibrosing alopecia (FFA) under dynamic optical coherence tomography (D-OCT)" @default.
- W2605913400 doi "https://doi.org/10.1016/j.jid.2017.02.887" @default.
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