Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605963676> ?p ?o ?g. }
- W2605963676 endingPage "35" @default.
- W2605963676 startingPage "35" @default.
- W2605963676 abstract "The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells. Fibroblasts are the predominant constituent of the tumor stroma and Hepatocyte Growth Factor (HGF), the specific ligand for the tyrosine kinase receptor c-MET, is a major component of their secretome. Indeed, cancer-associated fibroblasts have been shown to promote growth, survival and migration of cancer cells in an HGF-dependent manner. Fibroblasts also confer resistance to anti-cancer therapy through HGF-induced epithelial mesenchymal transition (EMT) and activation of pro-survival signaling pathways such as ERK and AKT in tumor cells. Constitutive HGF/MET signaling in cancer cells is associated with increased tumor aggressiveness and predicts poor outcome in cancer patients. Due to its role in tumor progression and therapeutic resistance, both HGF and MET have emerged as valid therapeutic targets. Several inhibitors of MET and HGF are currently being tested in clinical trials. Preclinical data provide a strong indication that inhibitors of HGF/MET signaling overcome both primary and acquired resistance to EGFR, HER2, and BRAF targeting agents. These findings support the notion that co-targeting of cancer cells and stromal cells is required to prevent therapeutic resistance and to increase the overall survival rate of cancer patients. HGF dependence has emerged as a hallmark of therapeutic resistance, suggesting that inhibitors of biological activity of HGF should be included into therapeutic regimens of cancer patients." @default.
- W2605963676 created "2017-04-28" @default.
- W2605963676 creator A5007823914 @default.
- W2605963676 creator A5044117839 @default.
- W2605963676 creator A5049539326 @default.
- W2605963676 creator A5070227595 @default.
- W2605963676 date "2017-04-17" @default.
- W2605963676 modified "2023-10-02" @default.
- W2605963676 title "Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment" @default.
- W2605963676 cites W1157613785 @default.
- W2605963676 cites W117902596 @default.
- W2605963676 cites W1516156637 @default.
- W2605963676 cites W1555777247 @default.
- W2605963676 cites W1771430734 @default.
- W2605963676 cites W1856175162 @default.
- W2605963676 cites W1924119154 @default.
- W2605963676 cites W1928129824 @default.
- W2605963676 cites W1943756471 @default.
- W2605963676 cites W1976556343 @default.
- W2605963676 cites W1977685008 @default.
- W2605963676 cites W1980839772 @default.
- W2605963676 cites W1981548531 @default.
- W2605963676 cites W1983940066 @default.
- W2605963676 cites W1985264867 @default.
- W2605963676 cites W1993574073 @default.
- W2605963676 cites W1996912024 @default.
- W2605963676 cites W1999025555 @default.
- W2605963676 cites W2001057991 @default.
- W2605963676 cites W2002937040 @default.
- W2605963676 cites W2003500892 @default.
- W2605963676 cites W2003984225 @default.
- W2605963676 cites W2005782838 @default.
- W2605963676 cites W2007040134 @default.
- W2605963676 cites W2007513598 @default.
- W2605963676 cites W2007904495 @default.
- W2605963676 cites W2008567068 @default.
- W2605963676 cites W2010537412 @default.
- W2605963676 cites W2011138678 @default.
- W2605963676 cites W2013678879 @default.
- W2605963676 cites W2019573100 @default.
- W2605963676 cites W2020115532 @default.
- W2605963676 cites W2021098045 @default.
- W2605963676 cites W2022495797 @default.
- W2605963676 cites W2024097402 @default.
- W2605963676 cites W2029695719 @default.
- W2605963676 cites W2033278321 @default.
- W2605963676 cites W2033751993 @default.
- W2605963676 cites W2034269086 @default.
- W2605963676 cites W2035252444 @default.
- W2605963676 cites W2036001925 @default.
- W2605963676 cites W2038143310 @default.
- W2605963676 cites W2039135880 @default.
- W2605963676 cites W2050254037 @default.
- W2605963676 cites W2050912734 @default.
- W2605963676 cites W2051469771 @default.
- W2605963676 cites W2052555886 @default.
- W2605963676 cites W2053966701 @default.
- W2605963676 cites W2055624262 @default.
- W2605963676 cites W2055908189 @default.
- W2605963676 cites W2056025993 @default.
- W2605963676 cites W2063192133 @default.
- W2605963676 cites W2067782874 @default.
- W2605963676 cites W2076577525 @default.
- W2605963676 cites W2076633367 @default.
- W2605963676 cites W2079905347 @default.
- W2605963676 cites W2080448684 @default.
- W2605963676 cites W2082046119 @default.
- W2605963676 cites W2085963386 @default.
- W2605963676 cites W2086585598 @default.
- W2605963676 cites W2087703581 @default.
- W2605963676 cites W2088110734 @default.
- W2605963676 cites W2089471687 @default.
- W2605963676 cites W2089739250 @default.
- W2605963676 cites W2093613683 @default.
- W2605963676 cites W2094337993 @default.
- W2605963676 cites W2096629477 @default.
- W2605963676 cites W2099750732 @default.
- W2605963676 cites W2100303404 @default.
- W2605963676 cites W2103810042 @default.
- W2605963676 cites W2104773257 @default.
- W2605963676 cites W2108516575 @default.
- W2605963676 cites W2109998353 @default.
- W2605963676 cites W2111566574 @default.
- W2605963676 cites W2114154136 @default.
- W2605963676 cites W2114383061 @default.
- W2605963676 cites W2116350465 @default.
- W2605963676 cites W2116904882 @default.
- W2605963676 cites W2117164669 @default.
- W2605963676 cites W2117692326 @default.
- W2605963676 cites W2119139616 @default.
- W2605963676 cites W2122895515 @default.
- W2605963676 cites W2126942356 @default.
- W2605963676 cites W2133129337 @default.
- W2605963676 cites W2138490473 @default.
- W2605963676 cites W2138896702 @default.
- W2605963676 cites W2144719083 @default.
- W2605963676 cites W2147650118 @default.
- W2605963676 cites W2148532468 @default.