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- W2606002989 abstract "The first step in the controlled storage of lengthy DNA molecules is to keep DNA molecules separated while integrated in micrometer-sized space. Herein, we present hybrid Monte Carlo simulations of a histone-complexed DNA (hcDNA) molecule confined in a dense array of nanoposts. Depending on the nanopost dimension, a single, 8.7 kilobase pair hcDNA molecule was either localized and elongated in a single inter-post space surrounded by four nanoposts or spread over several inter-post spaces through passages between two neighboring nanoposts. The conformational change of a hcDNA molecule is interpreted in terms of competitive effects of confinements in the inter-post and passage spaces. We propose that, by elaborately designing nanopost arrays, the competitive confinement effects can be adjusted such that each hcDNA molecule is localized in a single inter-post space, and thereby multiple hcDNA molecules can be physically separated from each other while stored together in the nanopost array." @default.
- W2606002989 created "2017-04-28" @default.
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- W2606002989 date "2017-01-01" @default.
- W2606002989 modified "2023-09-29" @default.
- W2606002989 title "Confinement-driven organization of a histone-complexed DNA molecule in a dense array of nanoposts" @default.
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- W2606002989 doi "https://doi.org/10.1039/c7nr00859g" @default.
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