Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606042248> ?p ?o ?g. }
- W2606042248 endingPage "404" @default.
- W2606042248 startingPage "393" @default.
- W2606042248 abstract "The therapeutic landscape of the Philadelphia-negative myeloproliferative neoplasms (MPNs) is markedly changing consequent to the development of JAK-inhibitors and the use of ruxolitinib (RUX) in patients with myelofibrosis (MF) and patients with polycythemia vera (PV) who develop refractoriness or intolerance to hydroxyurea. The use of Interferon-alpha2 (IFN) is rapidly expanding in several countries, based upon favourable safety and efficacy profiles in several single-arm studies during the last 30 years, displaying complete hematological remissions in a large proportion of patients, a reduction in the JAK2V617 F and CALR mutational burden and in a subset of patients with PV with normalisation of the bone marrow after long-term treatment - even being sustained for several years after discontinuation of IFN. To this end the concept of chronic inflammation as the driving force for MPN disease progression is being increasingly recognized. This novel concept has initiated phase II studies in patients with PV and MF of combination therapy with IFN and RUX. Areas covered and Expert commentary: Herein we highlight the background, the rationales and perspectives for this novel combinatorial approach which is foreseen as the most encouraging and promising treatment for patients with MPNs - hopefully with the potential of cure - at least operational cure - in a subset of patients." @default.
- W2606042248 created "2017-04-28" @default.
- W2606042248 creator A5025081753 @default.
- W2606042248 creator A5053726532 @default.
- W2606042248 date "2017-04-12" @default.
- W2606042248 modified "2023-10-18" @default.
- W2606042248 title "Minimal residual disease or cure in MPNs? Rationales and perspectives on combination therapy with interferon-alpha2 and ruxolitinib" @default.
- W2606042248 cites W1496068830 @default.
- W2606042248 cites W1547986283 @default.
- W2606042248 cites W1571845819 @default.
- W2606042248 cites W1793206271 @default.
- W2606042248 cites W1853969127 @default.
- W2606042248 cites W1884746267 @default.
- W2606042248 cites W1897524591 @default.
- W2606042248 cites W1906297732 @default.
- W2606042248 cites W1918141746 @default.
- W2606042248 cites W1947827851 @default.
- W2606042248 cites W1959044271 @default.
- W2606042248 cites W1964507871 @default.
- W2606042248 cites W1965037168 @default.
- W2606042248 cites W1966230381 @default.
- W2606042248 cites W1971183910 @default.
- W2606042248 cites W1971812559 @default.
- W2606042248 cites W1973499674 @default.
- W2606042248 cites W1974280095 @default.
- W2606042248 cites W1975135941 @default.
- W2606042248 cites W1978942726 @default.
- W2606042248 cites W1980568348 @default.
- W2606042248 cites W1982267544 @default.
- W2606042248 cites W1984960437 @default.
- W2606042248 cites W1986442976 @default.
- W2606042248 cites W1987517009 @default.
- W2606042248 cites W1991495650 @default.
- W2606042248 cites W1993072636 @default.
- W2606042248 cites W1995162107 @default.
- W2606042248 cites W1996636910 @default.
- W2606042248 cites W1998799939 @default.
- W2606042248 cites W2001466556 @default.
- W2606042248 cites W2001601358 @default.
- W2606042248 cites W2001645442 @default.
- W2606042248 cites W2002858572 @default.
- W2606042248 cites W2003848871 @default.
- W2606042248 cites W2007684724 @default.
- W2606042248 cites W2009657222 @default.
- W2606042248 cites W2010075352 @default.
- W2606042248 cites W2017903152 @default.
- W2606042248 cites W2020559061 @default.
- W2606042248 cites W2021705314 @default.
- W2606042248 cites W2023902889 @default.
- W2606042248 cites W2024706907 @default.
- W2606042248 cites W2024870800 @default.
- W2606042248 cites W2026413140 @default.
- W2606042248 cites W2027613124 @default.
- W2606042248 cites W2028334384 @default.
- W2606042248 cites W2030716854 @default.
- W2606042248 cites W2031251938 @default.
- W2606042248 cites W2034269086 @default.
- W2606042248 cites W2036363339 @default.
- W2606042248 cites W2037356292 @default.
- W2606042248 cites W2038488698 @default.
- W2606042248 cites W2043010327 @default.
- W2606042248 cites W2048488970 @default.
- W2606042248 cites W2049145190 @default.
- W2606042248 cites W2051154588 @default.
- W2606042248 cites W2054255660 @default.
- W2606042248 cites W2054753195 @default.
- W2606042248 cites W2054787206 @default.
- W2606042248 cites W2057129764 @default.
- W2606042248 cites W2057360098 @default.
- W2606042248 cites W2057650885 @default.
- W2606042248 cites W2058217708 @default.
- W2606042248 cites W2058330063 @default.
- W2606042248 cites W2060398075 @default.
- W2606042248 cites W2061962106 @default.
- W2606042248 cites W2067829130 @default.
- W2606042248 cites W2071377073 @default.
- W2606042248 cites W2071832964 @default.
- W2606042248 cites W2072881492 @default.
- W2606042248 cites W2094456737 @default.
- W2606042248 cites W2097692898 @default.
- W2606042248 cites W2097694060 @default.
- W2606042248 cites W2099264304 @default.
- W2606042248 cites W2100303019 @default.
- W2606042248 cites W2103280384 @default.
- W2606042248 cites W2106875723 @default.
- W2606042248 cites W2107139993 @default.
- W2606042248 cites W2107803729 @default.
- W2606042248 cites W2108630775 @default.
- W2606042248 cites W2110982533 @default.
- W2606042248 cites W2112316414 @default.
- W2606042248 cites W2114995805 @default.
- W2606042248 cites W2115351357 @default.
- W2606042248 cites W2116813423 @default.
- W2606042248 cites W2117692326 @default.
- W2606042248 cites W2119941797 @default.
- W2606042248 cites W2121743767 @default.
- W2606042248 cites W2122395736 @default.
- W2606042248 cites W2122567448 @default.