Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606042337> ?p ?o ?g. }
- W2606042337 endingPage "324" @default.
- W2606042337 startingPage "261" @default.
- W2606042337 abstract "Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two age-related amyloid diseases that affect millions of people worldwide. Broadly supported by epidemiological data, the higher incidence of AD among type 2 diabetic patients led to the recognition of T2D as a tangible risk factor for the development of AD. Indeed, there is now growing evidence on brain structural and functional abnormalities arising from brain insulin resistance and deficiency, ultimately highlighting the need for new approaches capable of preventing the development of AD in type 2 diabetic patients. This review provides an update on overlapping pathophysiological mechanisms and pathways in T2D and AD, such as amyloidogenic events, oxidative stress, endothelial dysfunction, aberrant enzymatic activity, and even shared genetic background. These events will be presented as puzzle pieces put together, thus establishing potential therapeutic targets for drug discovery and development against T2D and diabetes-induced cognitive decline-a heavyweight contributor to the increasing incidence of dementia in developed countries. Hoping to pave the way in this direction, we will present some of the most promising and well-studied drug leads with potential against both pathologies, including their respective bioactivity reports, mechanisms of action, and structure-activity relationships." @default.
- W2606042337 created "2017-04-28" @default.
- W2606042337 creator A5045177707 @default.
- W2606042337 creator A5056800453 @default.
- W2606042337 creator A5058166957 @default.
- W2606042337 date "2017-04-19" @default.
- W2606042337 modified "2023-10-14" @default.
- W2606042337 title "Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential" @default.
- W2606042337 cites W1029387585 @default.
- W2606042337 cites W106337374 @default.
- W2606042337 cites W1080829873 @default.
- W2606042337 cites W1140799991 @default.
- W2606042337 cites W1211379925 @default.
- W2606042337 cites W1275014322 @default.
- W2606042337 cites W1481075775 @default.
- W2606042337 cites W1481733466 @default.
- W2606042337 cites W1496563272 @default.
- W2606042337 cites W1506717124 @default.
- W2606042337 cites W1511202363 @default.
- W2606042337 cites W1513401887 @default.
- W2606042337 cites W1513524694 @default.
- W2606042337 cites W1515929023 @default.
- W2606042337 cites W1522284801 @default.
- W2606042337 cites W153725173 @default.
- W2606042337 cites W1546531859 @default.
- W2606042337 cites W1546896514 @default.
- W2606042337 cites W1548494899 @default.
- W2606042337 cites W1550156414 @default.
- W2606042337 cites W1550871940 @default.
- W2606042337 cites W1564825167 @default.
- W2606042337 cites W1567624342 @default.
- W2606042337 cites W1570713016 @default.
- W2606042337 cites W1590376803 @default.
- W2606042337 cites W1592686897 @default.
- W2606042337 cites W1616122655 @default.
- W2606042337 cites W1642912455 @default.
- W2606042337 cites W1645987148 @default.
- W2606042337 cites W1686063660 @default.
- W2606042337 cites W1711669283 @default.
- W2606042337 cites W1761048066 @default.
- W2606042337 cites W1793903715 @default.
- W2606042337 cites W1808665424 @default.
- W2606042337 cites W1824477449 @default.
- W2606042337 cites W1837066325 @default.
- W2606042337 cites W184255001 @default.
- W2606042337 cites W1852117537 @default.
- W2606042337 cites W1854174126 @default.
- W2606042337 cites W1868589471 @default.
- W2606042337 cites W1875253544 @default.
- W2606042337 cites W1880875467 @default.
- W2606042337 cites W1881992150 @default.
- W2606042337 cites W1886477676 @default.
- W2606042337 cites W1891882247 @default.
- W2606042337 cites W1895530546 @default.
- W2606042337 cites W1897469256 @default.
- W2606042337 cites W1900420888 @default.
- W2606042337 cites W1923616468 @default.
- W2606042337 cites W1930926196 @default.
- W2606042337 cites W1935669829 @default.
- W2606042337 cites W1943042349 @default.
- W2606042337 cites W1949021316 @default.
- W2606042337 cites W1952040396 @default.
- W2606042337 cites W1963939294 @default.
- W2606042337 cites W1964502805 @default.
- W2606042337 cites W1964971448 @default.
- W2606042337 cites W1965223596 @default.
- W2606042337 cites W1965496447 @default.
- W2606042337 cites W1966116864 @default.
- W2606042337 cites W1966618264 @default.
- W2606042337 cites W1967239550 @default.
- W2606042337 cites W1967374306 @default.
- W2606042337 cites W1967493721 @default.
- W2606042337 cites W1968026951 @default.
- W2606042337 cites W1968392599 @default.
- W2606042337 cites W1968436653 @default.
- W2606042337 cites W1968598354 @default.
- W2606042337 cites W1968974260 @default.
- W2606042337 cites W1969889278 @default.
- W2606042337 cites W1970048642 @default.
- W2606042337 cites W1970164987 @default.
- W2606042337 cites W1970843597 @default.
- W2606042337 cites W1970977633 @default.
- W2606042337 cites W1971095698 @default.
- W2606042337 cites W1971593160 @default.
- W2606042337 cites W1972436174 @default.
- W2606042337 cites W1972609075 @default.
- W2606042337 cites W1973479349 @default.
- W2606042337 cites W1974266381 @default.
- W2606042337 cites W1975140802 @default.
- W2606042337 cites W1975792122 @default.
- W2606042337 cites W1976194786 @default.
- W2606042337 cites W1976619844 @default.
- W2606042337 cites W1977268662 @default.
- W2606042337 cites W1979426131 @default.
- W2606042337 cites W1980189838 @default.
- W2606042337 cites W1980494536 @default.
- W2606042337 cites W1980543790 @default.
- W2606042337 cites W1981101710 @default.