FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606046835> ?p ?o ?g. }

• W2606046835 endingPage "e0175707" @default.
• W2606046835 startingPage "e0175707" @default.
• W2606046835 abstract "Streptococcus pyogenes (group A streptococcus, GAS) is responsible for a wide array of infections. Respiratory transmission via droplets is the most common mode of transmission but it may also infect the host via other routes such as lesions in the skin. To advance the development of a future vaccine against GAS, it is therefore important to investigate how protective immunity is related to the route of vaccine administration. To explore this, we examined whether a parenterally administered anti-GAS vaccine could protect against an intranasal GAS infection or if this would require locally primed immunity. We foundd that a parenteral CAF01 adjuvanted GAS vaccine offered no protection against intranasal infection despite inducing strong systemic Th1/Th17/IgG immunity that efficiently protected against an intraperitoneal GAS infection. However, the same vaccine administered via the intranasal route was able to induce protection against repeated intranasal GAS infections in a murine challenge model. The lack of intranasal protection induced by the parenteral vaccine correlated with a reduced mucosal recall response at the site of infection. Taken together, our results demonstrate that locally primed immunity is important for the defense against intranasal infection with Streptococcus pyogenes." @default.
• W2606046835 created "2017-04-28" @default.
• W2606046835 creator A5012450083 @default.
• W2606046835 creator A5034593036 @default.
• W2606046835 creator A5051891980 @default.
• W2606046835 creator A5073836581 @default.
• W2606046835 creator A5088726380 @default.
• W2606046835 creator A5090428914 @default.
• W2606046835 date "2017-04-17" @default.
• W2606046835 modified "2023-10-06" @default.
• W2606046835 title "Local Th17/IgA immunity correlate with protection against intranasal infection with Streptococcus pyogenes" @default.
• W2606046835 cites W1526879038 @default.
• W2606046835 cites W1563081886 @default.
• W2606046835 cites W1573380982 @default.
• W2606046835 cites W1576677426 @default.
• W2606046835 cites W1583569488 @default.
• W2606046835 cites W1637811627 @default.
• W2606046835 cites W1751404917 @default.
• W2606046835 cites W1896084611 @default.
• W2606046835 cites W1974314938 @default.
• W2606046835 cites W1991072710 @default.
• W2606046835 cites W1992062386 @default.
• W2606046835 cites W1994277319 @default.
• W2606046835 cites W2001194497 @default.
• W2606046835 cites W2001553535 @default.
• W2606046835 cites W2001643095 @default.
• W2606046835 cites W2002993124 @default.
• W2606046835 cites W2015622010 @default.
• W2606046835 cites W2016669409 @default.
• W2606046835 cites W2016837553 @default.
• W2606046835 cites W2018393191 @default.
• W2606046835 cites W2024916519 @default.
• W2606046835 cites W2035661165 @default.
• W2606046835 cites W2037123168 @default.
• W2606046835 cites W2044598071 @default.
• W2606046835 cites W2048756080 @default.
• W2606046835 cites W2058732187 @default.
• W2606046835 cites W2060023876 @default.
• W2606046835 cites W2060993096 @default.
• W2606046835 cites W2062724873 @default.
• W2606046835 cites W2083184841 @default.
• W2606046835 cites W2095483628 @default.
• W2606046835 cites W2108147481 @default.
• W2606046835 cites W2115330656 @default.
• W2606046835 cites W2120639651 @default.
• W2606046835 cites W2123786729 @default.
• W2606046835 cites W2135403001 @default.
• W2606046835 cites W2137613681 @default.
• W2606046835 cites W2158557662 @default.
• W2606046835 cites W2193035958 @default.
• W2606046835 cites W2330278582 @default.
• W2606046835 cites W233544536 @default.
• W2606046835 cites W4239746398 @default.
• W2606046835 doi "https://doi.org/10.1371/journal.pone.0175707" @default.
• W2606046835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5393599" @default.
• W2606046835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28414746" @default.
• W2606046835 hasPublicationYear "2017" @default.
• W2606046835 type Work @default.
• W2606046835 sameAs 2606046835 @default.
• W2606046835 citedByCount "18" @default.
• W2606046835 countsByYear W26060468352018 @default.
• W2606046835 countsByYear W26060468352019 @default.
• W2606046835 countsByYear W26060468352020 @default.
• W2606046835 countsByYear W26060468352021 @default.
• W2606046835 countsByYear W26060468352022 @default.
• W2606046835 countsByYear W26060468352023 @default.
• W2606046835 crossrefType "journal-article" @default.
• W2606046835 hasAuthorship W2606046835A5012450083 @default.
• W2606046835 hasAuthorship W2606046835A5034593036 @default.
• W2606046835 hasAuthorship W2606046835A5051891980 @default.
• W2606046835 hasAuthorship W2606046835A5073836581 @default.
• W2606046835 hasAuthorship W2606046835A5088726380 @default.
• W2606046835 hasAuthorship W2606046835A5090428914 @default.
• W2606046835 hasBestOaLocation W26060468351 @default.
• W2606046835 hasConcept C119599485 @default.
• W2606046835 hasConcept C127413603 @default.
• W2606046835 hasConcept C159047783 @default.
• W2606046835 hasConcept C203014093 @default.
• W2606046835 hasConcept C22070199 @default.
• W2606046835 hasConcept C2778276568 @default.
• W2606046835 hasConcept C2779306812 @default.
• W2606046835 hasConcept C2779341262 @default.
• W2606046835 hasConcept C2779489039 @default.
• W2606046835 hasConcept C523546767 @default.
• W2606046835 hasConcept C54355233 @default.
• W2606046835 hasConcept C71924100 @default.
• W2606046835 hasConcept C761482 @default.
• W2606046835 hasConcept C85663871 @default.
• W2606046835 hasConcept C86803240 @default.
• W2606046835 hasConcept C8891405 @default.
• W2606046835 hasConcept C89423630 @default.
• W2606046835 hasConceptScore W2606046835C119599485 @default.
• W2606046835 hasConceptScore W2606046835C127413603 @default.
• W2606046835 hasConceptScore W2606046835C159047783 @default.
• W2606046835 hasConceptScore W2606046835C203014093 @default.
• W2606046835 hasConceptScore W2606046835C22070199 @default.
• W2606046835 hasConceptScore W2606046835C2778276568 @default.
• W2606046835 hasConceptScore W2606046835C2779306812 @default.

• next