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• W2606091851 startingPage "e596" @default.
• W2606091851 abstract "Chronic pain is a common and debilitating complication following breast surgery. One of the most challenging for treatment is the neuropathic pain condition, postmastectomy pain syndrome (PMPS). Gabapentin is a pharmacotherapy for neuropathic pain disorders; however, its once-daily, gastroretentive formulation, Gralise, has not been evaluated in PMPS.To evaluate the safety and effectiveness of Gralise in patients with moderate-to-severe PMPS.The primary effectiveness endpoint was a change in the worst pain intensity score from baseline to completion of 8 weeks of Gralise therapy. The secondary endpoints included the change in mood, coping behavior, sleep, and function. Sensitivity to experimental stimuli was tested before and after treatment via quantitative sensory testing. The incidence and type of adverse event were used to evaluate the safety and tolerability of Gralise.Twenty-one patients with confirmed moderate-to-severe PMPS were enrolled. Nineteen of 21 (90.5%) patients completed the 8-week treatment with Gralise. A significant positive change was found in pain intensity, pain impact, and sleep. There was no change in sensory testing scores. Of total, 63.16% of patients reported reduction in present pain, 78.95% in average pain, 89.47% in worst pain, and 84.21% in overall pain severity at posttreatment visit. No significant adverse effects were noted in the study.Variation in type of breast surgery, small sample size, lack of placebo control.There was a significant improvement in pain and sleep, and Gralise was well tolerated in patients with PMPS. Further investigation is warranted." @default.
• W2606091851 created "2017-04-28" @default.
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• W2606091851 date "2017-05-01" @default.
• W2606091851 modified "2023-09-27" @default.
• W2606091851 title "Effect of gastroretentive gabapentin (Gralise) on postmastectomy pain syndrome: a proof-of-principle open-label study" @default.
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• W2606091851 doi "https://doi.org/10.1097/pr9.0000000000000596" @default.
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• W2606091851 hasPublicationYear "2017" @default.
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