Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606093896> ?p ?o ?g. }
- W2606093896 endingPage "81" @default.
- W2606093896 startingPage "67" @default.
- W2606093896 abstract "Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestige of their original genome (mtDNA), and its corresponding full gene expression machinery. Proteins encoded in the mtDNA, all components of the multimeric OXPHOS enzymes, are synthesized in specialized mitochondrial ribosomes (mitoribosomes). Mitoribosomes are therefore essential in the regulation of cellular respiration. Additionally, an increasing body of literature has been reporting an alternative role for several mitochondrial ribosomal proteins as apoptosis-inducing factors. No surprisingly, the expression of genes encoding for mitoribosomal proteins, mitoribosome assembly factors and mitochondrial translation factors is modified in numerous cancers, a trait that has been linked to tumorigenesis and metastasis. In this article, we will review the current knowledge regarding the dual function of mitoribosome components in protein synthesis and apoptosis and their association with cancer susceptibility and development. We will also highlight recent developments in targeting mitochondrial ribosomes for the treatment of cancer." @default.
- W2606093896 created "2017-04-28" @default.
- W2606093896 creator A5035747698 @default.
- W2606093896 creator A5058602584 @default.
- W2606093896 creator A5073384154 @default.
- W2606093896 date "2017-12-01" @default.
- W2606093896 modified "2023-10-14" @default.
- W2606093896 title "Mitochondrial ribosomes in cancer" @default.
- W2606093896 cites W1027356788 @default.
- W2606093896 cites W111217621 @default.
- W2606093896 cites W1487823280 @default.
- W2606093896 cites W1489829446 @default.
- W2606093896 cites W1495043240 @default.
- W2606093896 cites W1499730823 @default.
- W2606093896 cites W1501080271 @default.
- W2606093896 cites W1533541966 @default.
- W2606093896 cites W1554617000 @default.
- W2606093896 cites W1577790096 @default.
- W2606093896 cites W1581697291 @default.
- W2606093896 cites W1614372115 @default.
- W2606093896 cites W1707356941 @default.
- W2606093896 cites W1871148721 @default.
- W2606093896 cites W1902911958 @default.
- W2606093896 cites W1963535936 @default.
- W2606093896 cites W1963636235 @default.
- W2606093896 cites W1963795701 @default.
- W2606093896 cites W1964333133 @default.
- W2606093896 cites W1966732894 @default.
- W2606093896 cites W1967222028 @default.
- W2606093896 cites W1968453995 @default.
- W2606093896 cites W1970073870 @default.
- W2606093896 cites W1970748323 @default.
- W2606093896 cites W1975529948 @default.
- W2606093896 cites W1977145129 @default.
- W2606093896 cites W1977368092 @default.
- W2606093896 cites W1978921497 @default.
- W2606093896 cites W1979129444 @default.
- W2606093896 cites W1980032214 @default.
- W2606093896 cites W1980512756 @default.
- W2606093896 cites W1980759551 @default.
- W2606093896 cites W1981903391 @default.
- W2606093896 cites W1986403448 @default.
- W2606093896 cites W1989246472 @default.
- W2606093896 cites W1991299254 @default.
- W2606093896 cites W1992057876 @default.
- W2606093896 cites W1992071355 @default.
- W2606093896 cites W1992958104 @default.
- W2606093896 cites W1996822667 @default.
- W2606093896 cites W1996993889 @default.
- W2606093896 cites W2000847783 @default.
- W2606093896 cites W2001485008 @default.
- W2606093896 cites W2002922559 @default.
- W2606093896 cites W2003594175 @default.
- W2606093896 cites W2004628029 @default.
- W2606093896 cites W2006035995 @default.
- W2606093896 cites W2010249331 @default.
- W2606093896 cites W2011344898 @default.
- W2606093896 cites W2011813312 @default.
- W2606093896 cites W2014420442 @default.
- W2606093896 cites W2015178379 @default.
- W2606093896 cites W2016876355 @default.
- W2606093896 cites W2017184871 @default.
- W2606093896 cites W2018062480 @default.
- W2606093896 cites W2018813204 @default.
- W2606093896 cites W2021319080 @default.
- W2606093896 cites W2022955673 @default.
- W2606093896 cites W2024376580 @default.
- W2606093896 cites W2027363154 @default.
- W2606093896 cites W2027676112 @default.
- W2606093896 cites W2029406352 @default.
- W2606093896 cites W2031166525 @default.
- W2606093896 cites W2031795384 @default.
- W2606093896 cites W2032333621 @default.
- W2606093896 cites W2033735406 @default.
- W2606093896 cites W2034773856 @default.
- W2606093896 cites W2034984753 @default.
- W2606093896 cites W2035392010 @default.
- W2606093896 cites W2037134079 @default.
- W2606093896 cites W2037456549 @default.
- W2606093896 cites W2037507604 @default.
- W2606093896 cites W2037920583 @default.
- W2606093896 cites W2040032718 @default.
- W2606093896 cites W2041851797 @default.
- W2606093896 cites W2044710235 @default.
- W2606093896 cites W2046245331 @default.
- W2606093896 cites W2048485231 @default.
- W2606093896 cites W2048619749 @default.
- W2606093896 cites W2049185877 @default.
- W2606093896 cites W2050670061 @default.
- W2606093896 cites W2051937183 @default.
- W2606093896 cites W2058236972 @default.
- W2606093896 cites W2058244193 @default.
- W2606093896 cites W2059613997 @default.
- W2606093896 cites W2059902796 @default.
- W2606093896 cites W2060003051 @default.
- W2606093896 cites W2061594903 @default.
- W2606093896 cites W2062408850 @default.
- W2606093896 cites W2062738629 @default.