Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606142502> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2606142502 endingPage "1" @default.
- W2606142502 startingPage "1" @default.
- W2606142502 abstract "Objective: This study aims to examine markers of coagulation activation and their possible clinical associations in sickle cell disease (SCD) and thalassemia.Materials And Methods: This study was conducted on patients with hemoglobinopathy followed up at King Abdulaziz University Hospital between October 2010 and November 2011. Demographic and clinical data were collected for all participants. The independent t-test was used to compare two group means, while the one-way analysis of variance test was used to compare more than two group means.Results: The study included 122 hemoglobinopathy cases and 34 controls. Protein C, protein S, antithrombin, and activated protein C resistance (APCR) were significantly lower in patients with hemoglobinopathy than in the control group, while D-dimer levels were significantly higher (P < 0.001 for all comparisons). Patients with SCD had significantly higher protein C and D-dimer levels than those who had thalassemia (P < 0.01 for both). Arterial and venous thromboses were more prevalent in patients with SCD (12.5 and 18.7%), compared to patients with thalassemia (9.3 and 2.3%, respectively). Cases had significantly lower protein C, protein S, antithrombin, and APCR values (P < 0.001 for each), and higher D-dimer levels (P = 0.016) than male controls. There was no significant difference in markers of coagulation activation between patients who had undergone splenectomy compared with those who had intact spleens.Conclusion: Natural anticoagulants were significantly lower, and D-dimer levels were higher in Saudi patients with SCD and thalassemia compared to healthy controls. The procoagulant phenotype was more pronounced in patients with SCD and was associated with a higher prevalence of clinical thrombosis, compared to patients with thalassemia in this population." @default.
- W2606142502 created "2017-04-28" @default.
- W2606142502 creator A5011860608 @default.
- W2606142502 creator A5080124333 @default.
- W2606142502 date "2017-01-01" @default.
- W2606142502 modified "2023-09-27" @default.
- W2606142502 title "Markers of coagulation activation in patients with hemoglobinopathy in Western Saudi Arabia" @default.
- W2606142502 cites W1663316730 @default.
- W2606142502 cites W2562751034 @default.
- W2606142502 doi "https://doi.org/10.4103/1658-5127.204426" @default.
- W2606142502 hasPublicationYear "2017" @default.
- W2606142502 type Work @default.
- W2606142502 sameAs 2606142502 @default.
- W2606142502 citedByCount "0" @default.
- W2606142502 crossrefType "journal-article" @default.
- W2606142502 hasAuthorship W2606142502A5011860608 @default.
- W2606142502 hasAuthorship W2606142502A5080124333 @default.
- W2606142502 hasBestOaLocation W26061425021 @default.
- W2606142502 hasConcept C126322002 @default.
- W2606142502 hasConcept C2776135265 @default.
- W2606142502 hasConcept C2777175894 @default.
- W2606142502 hasConcept C2777557582 @default.
- W2606142502 hasConcept C2777799968 @default.
- W2606142502 hasConcept C2779026020 @default.
- W2606142502 hasConcept C2779134260 @default.
- W2606142502 hasConcept C2779519742 @default.
- W2606142502 hasConcept C2779668550 @default.
- W2606142502 hasConcept C2779956388 @default.
- W2606142502 hasConcept C2780011451 @default.
- W2606142502 hasConcept C2780868729 @default.
- W2606142502 hasConcept C2781287897 @default.
- W2606142502 hasConcept C71924100 @default.
- W2606142502 hasConcept C90924648 @default.
- W2606142502 hasConceptScore W2606142502C126322002 @default.
- W2606142502 hasConceptScore W2606142502C2776135265 @default.
- W2606142502 hasConceptScore W2606142502C2777175894 @default.
- W2606142502 hasConceptScore W2606142502C2777557582 @default.
- W2606142502 hasConceptScore W2606142502C2777799968 @default.
- W2606142502 hasConceptScore W2606142502C2779026020 @default.
- W2606142502 hasConceptScore W2606142502C2779134260 @default.
- W2606142502 hasConceptScore W2606142502C2779519742 @default.
- W2606142502 hasConceptScore W2606142502C2779668550 @default.
- W2606142502 hasConceptScore W2606142502C2779956388 @default.
- W2606142502 hasConceptScore W2606142502C2780011451 @default.
- W2606142502 hasConceptScore W2606142502C2780868729 @default.
- W2606142502 hasConceptScore W2606142502C2781287897 @default.
- W2606142502 hasConceptScore W2606142502C71924100 @default.
- W2606142502 hasConceptScore W2606142502C90924648 @default.
- W2606142502 hasIssue "1" @default.
- W2606142502 hasLocation W26061425021 @default.
- W2606142502 hasOpenAccess W2606142502 @default.
- W2606142502 hasPrimaryLocation W26061425021 @default.
- W2606142502 hasRelatedWork W1991819107 @default.
- W2606142502 hasRelatedWork W2007525775 @default.
- W2606142502 hasRelatedWork W2036123550 @default.
- W2606142502 hasRelatedWork W2077900537 @default.
- W2606142502 hasRelatedWork W2097047598 @default.
- W2606142502 hasRelatedWork W2411298939 @default.
- W2606142502 hasRelatedWork W2461745222 @default.
- W2606142502 hasRelatedWork W2562751034 @default.
- W2606142502 hasRelatedWork W2587926608 @default.
- W2606142502 hasRelatedWork W2606142502 @default.
- W2606142502 hasVolume "8" @default.
- W2606142502 isParatext "false" @default.
- W2606142502 isRetracted "false" @default.
- W2606142502 magId "2606142502" @default.
- W2606142502 workType "article" @default.