FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606150498> ?p ?o ?g. }

• W2606150498 abstract "ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidity and mortality in humans. After infection with SARS-CoV, the acute lung injury caused by the virus must be repaired to regain lung function. A dysregulation in this wound healing process leads to fibrosis. Many survivors of SARS-CoV infection develop pulmonary fibrosis (PF), with higher prevalence in older patients. Using mouse models of SARS-CoV pathogenesis, we have identified that the wound repair pathway, controlled by the epidermal growth factor receptor (EGFR), is critical to recovery from SARS-CoV-induced tissue damage. In mice with constitutively active EGFR [EGFR(DSK5) mice], we find that SARS-CoV infection causes enhanced lung disease. Importantly, we show that during infection, the EGFR ligands amphiregulin and heparin-binding EGF-like growth factor (HB-EGF) are upregulated, and exogenous addition of these ligands during infection leads to enhanced lung disease and altered wound healing dynamics. Our data demonstrate a key role of EGFR in the host response to SARS-CoV and how it may be implicated in lung disease induced by other highly pathogenic respiratory viruses. IMPORTANCE PF has many causative triggers, including severe respiratory viruses such as SARS-CoV. Currently there are no treatments to prevent the onset or limit the progression of PF, and the molecular pathways underlying the development of PF are not well understood. In this study, we identified a role for the balanced control of EGFR signaling as a key factor in progression to PF. These data demonstrate that therapeutic treatment modulating EGFR activation could protect against PF development caused by severe respiratory virus infection." @default.
• W2606150498 created "2017-04-28" @default.
• W2606150498 creator A5012708409 @default.
• W2606150498 creator A5034246875 @default.
• W2606150498 creator A5083562890 @default.
• W2606150498 date "2017-06-15" @default.
• W2606150498 modified "2023-10-16" @default.
• W2606150498 title "Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection" @default.
• W2606150498 cites W1546965101 @default.
• W2606150498 cites W1931315964 @default.
• W2606150498 cites W1963580683 @default.
• W2606150498 cites W1970860163 @default.
• W2606150498 cites W1980321651 @default.
• W2606150498 cites W1980325398 @default.
• W2606150498 cites W1981269419 @default.
• W2606150498 cites W1983357763 @default.
• W2606150498 cites W1988466760 @default.
• W2606150498 cites W1992913621 @default.
• W2606150498 cites W2002481497 @default.
• W2606150498 cites W2006633411 @default.
• W2606150498 cites W2014355881 @default.
• W2606150498 cites W2017047335 @default.
• W2606150498 cites W2020907530 @default.
• W2606150498 cites W2024502310 @default.
• W2606150498 cites W2030298463 @default.
• W2606150498 cites W2032681736 @default.
• W2606150498 cites W2036537825 @default.
• W2606150498 cites W2039685773 @default.
• W2606150498 cites W2045142779 @default.
• W2606150498 cites W2046501504 @default.
• W2606150498 cites W2048353858 @default.
• W2606150498 cites W2049537492 @default.
• W2606150498 cites W2051056083 @default.
• W2606150498 cites W2063732933 @default.
• W2606150498 cites W2064307892 @default.
• W2606150498 cites W2066650952 @default.
• W2606150498 cites W2069076782 @default.
• W2606150498 cites W2077624007 @default.
• W2606150498 cites W2082543204 @default.
• W2606150498 cites W2084824122 @default.
• W2606150498 cites W2086933932 @default.
• W2606150498 cites W2087178648 @default.
• W2606150498 cites W2093440393 @default.
• W2606150498 cites W2096096763 @default.
• W2606150498 cites W2098436002 @default.
• W2606150498 cites W2100706096 @default.
• W2606150498 cites W2112964787 @default.
• W2606150498 cites W2116634113 @default.
• W2606150498 cites W2116762360 @default.
• W2606150498 cites W2119968951 @default.
• W2606150498 cites W2120865735 @default.
• W2606150498 cites W2120959382 @default.
• W2606150498 cites W2122355964 @default.
• W2606150498 cites W2122712858 @default.
• W2606150498 cites W2124413369 @default.
• W2606150498 cites W2124509026 @default.
• W2606150498 cites W2133632488 @default.
• W2606150498 cites W2138642580 @default.
• W2606150498 cites W2139841187 @default.
• W2606150498 cites W2142605112 @default.
• W2606150498 cites W2149784485 @default.
• W2606150498 cites W2155958456 @default.
• W2606150498 cites W2157869208 @default.
• W2606150498 cites W2161155632 @default.
• W2606150498 cites W2167521946 @default.
• W2606150498 cites W2168565849 @default.
• W2606150498 cites W2169981609 @default.
• W2606150498 cites W2170989872 @default.
• W2606150498 cites W2183739716 @default.
• W2606150498 cites W2186455790 @default.
• W2606150498 cites W2267742187 @default.
• W2606150498 cites W2340083901 @default.
• W2606150498 cites W2410910046 @default.
• W2606150498 cites W2504315529 @default.
• W2606150498 cites W2521027544 @default.
• W2606150498 doi "https://doi.org/10.1128/jvi.00182-17" @default.
• W2606150498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5446658" @default.
• W2606150498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28404843" @default.
• W2606150498 hasPublicationYear "2017" @default.
• W2606150498 type Work @default.
• W2606150498 sameAs 2606150498 @default.
• W2606150498 citedByCount "78" @default.
• W2606150498 countsByYear W26061504982018 @default.
• W2606150498 countsByYear W26061504982019 @default.
• W2606150498 countsByYear W26061504982020 @default.
• W2606150498 countsByYear W26061504982021 @default.
• W2606150498 countsByYear W26061504982022 @default.
• W2606150498 countsByYear W26061504982023 @default.
• W2606150498 crossrefType "journal-article" @default.
• W2606150498 hasAuthorship W2606150498A5012708409 @default.
• W2606150498 hasAuthorship W2606150498A5034246875 @default.
• W2606150498 hasAuthorship W2606150498A5083562890 @default.
• W2606150498 hasBestOaLocation W26061504982 @default.
• W2606150498 hasConcept C126322002 @default.
• W2606150498 hasConcept C142724271 @default.
• W2606150498 hasConcept C170493617 @default.
• W2606150498 hasConcept C203014093 @default.
• W2606150498 hasConcept C2776362946 @default.
• W2606150498 hasConcept C2776938444 @default.
• W2606150498 hasConcept C2777714996 @default.

• next