FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606262012> ?p ?o ?g. }

• W2606262012 abstract "Abstract Glycosaminoglycans are known to bind biological mediators thereby modulating their biological activity. Sulfated hyaluronans (sHA) were reported to strongly interact with transforming growth factor (TGF)-β1 leading to impaired bioactivity in fibroblasts. The underlying mechanism is not fully elucidated yet. Examining the interaction of all components of the TGF-β1:receptor complex with sHA by surface plasmon resonance, we could show that highly sulfated HA (sHA3) blocks binding of TGF-β1 to its TGF-β receptor-I (TβR-I) and -II (TβR-II). However, sequential addition of sHA3 to the TβR-II/TGF-β1 complex led to a significantly stronger recruitment of TβR-I compared to a complex lacking sHA3, indicating that the order of binding events is very important. Molecular modeling suggested a possible molecular mechanism in which sHA3 could potentially favor the association of TβR-I when added sequentially. For the first time bioactivity of TGF-β1 in conjunction with sHA was investigated at the receptor level. TβR-I and, furthermore, Smad2 phosphorylation were decreased in the presence of sHA3 indicating the formation of an inactive signaling complex. The results contribute to an improved understanding of the interference of sHA3 with TGF-β1:receptor complex formation and will help to further improve the design of functional biomaterials that interfere with TGF-β1-driven skin fibrosis." @default.
• W2606262012 created "2017-04-28" @default.
• W2606262012 creator A5000630674 @default.
• W2606262012 creator A5006925287 @default.
• W2606262012 creator A5021400024 @default.
• W2606262012 creator A5026980114 @default.
• W2606262012 creator A5045304852 @default.
• W2606262012 creator A5045665079 @default.
• W2606262012 creator A5055531234 @default.
• W2606262012 creator A5061336944 @default.
• W2606262012 creator A5068577941 @default.
• W2606262012 creator A5075134870 @default.
• W2606262012 creator A5086671958 @default.
• W2606262012 creator A5087980174 @default.
• W2606262012 date "2017-04-26" @default.
• W2606262012 modified "2023-10-03" @default.
• W2606262012 title "Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling" @default.
• W2606262012 cites W1494055834 @default.
• W2606262012 cites W1601394191 @default.
• W2606262012 cites W1895323715 @default.
• W2606262012 cites W1963767618 @default.
• W2606262012 cites W1965536188 @default.
• W2606262012 cites W1968881409 @default.
• W2606262012 cites W1970727036 @default.
• W2606262012 cites W1973003441 @default.
• W2606262012 cites W1974985218 @default.
• W2606262012 cites W1978599711 @default.
• W2606262012 cites W2012180376 @default.
• W2606262012 cites W2012664610 @default.
• W2606262012 cites W2021263701 @default.
• W2606262012 cites W2022660390 @default.
• W2606262012 cites W2027844145 @default.
• W2606262012 cites W2035653659 @default.
• W2606262012 cites W2035932215 @default.
• W2606262012 cites W2037027126 @default.
• W2606262012 cites W2037438505 @default.
• W2606262012 cites W2039467532 @default.
• W2606262012 cites W2040854254 @default.
• W2606262012 cites W2046820460 @default.
• W2606262012 cites W2050928977 @default.
• W2606262012 cites W2051816002 @default.
• W2606262012 cites W2055380229 @default.
• W2606262012 cites W2057538896 @default.
• W2606262012 cites W2086692663 @default.
• W2606262012 cites W2088671938 @default.
• W2606262012 cites W2095605427 @default.
• W2606262012 cites W2102298863 @default.
• W2606262012 cites W2106389977 @default.
• W2606262012 cites W2111952057 @default.
• W2606262012 cites W2133193835 @default.
• W2606262012 cites W2153203105 @default.
• W2606262012 cites W2154568166 @default.
• W2606262012 cites W2158534713 @default.
• W2606262012 cites W2164401552 @default.
• W2606262012 cites W2282008960 @default.
• W2606262012 cites W2315063842 @default.
• W2606262012 cites W2335187016 @default.
• W2606262012 cites W873312259 @default.
• W2606262012 doi "https://doi.org/10.1038/s41598-017-01264-8" @default.
• W2606262012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5430790" @default.
• W2606262012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28446792" @default.
• W2606262012 hasPublicationYear "2017" @default.
• W2606262012 type Work @default.
• W2606262012 sameAs 2606262012 @default.
• W2606262012 citedByCount "30" @default.
• W2606262012 countsByYear W26062620122018 @default.
• W2606262012 countsByYear W26062620122019 @default.
• W2606262012 countsByYear W26062620122020 @default.
• W2606262012 countsByYear W26062620122021 @default.
• W2606262012 countsByYear W26062620122022 @default.
• W2606262012 countsByYear W26062620122023 @default.
• W2606262012 crossrefType "journal-article" @default.
• W2606262012 hasAuthorship W2606262012A5000630674 @default.
• W2606262012 hasAuthorship W2606262012A5006925287 @default.
• W2606262012 hasAuthorship W2606262012A5021400024 @default.
• W2606262012 hasAuthorship W2606262012A5026980114 @default.
• W2606262012 hasAuthorship W2606262012A5045304852 @default.
• W2606262012 hasAuthorship W2606262012A5045665079 @default.
• W2606262012 hasAuthorship W2606262012A5055531234 @default.
• W2606262012 hasAuthorship W2606262012A5061336944 @default.
• W2606262012 hasAuthorship W2606262012A5068577941 @default.
• W2606262012 hasAuthorship W2606262012A5075134870 @default.
• W2606262012 hasAuthorship W2606262012A5086671958 @default.
• W2606262012 hasAuthorship W2606262012A5087980174 @default.
• W2606262012 hasBestOaLocation W26062620121 @default.
• W2606262012 hasConcept C106847996 @default.
• W2606262012 hasConcept C118131993 @default.
• W2606262012 hasConcept C125555471 @default.
• W2606262012 hasConcept C126322002 @default.
• W2606262012 hasConcept C155138218 @default.
• W2606262012 hasConcept C155672457 @default.
• W2606262012 hasConcept C170493617 @default.
• W2606262012 hasConcept C171250308 @default.
• W2606262012 hasConcept C185592680 @default.
• W2606262012 hasConcept C192562407 @default.
• W2606262012 hasConcept C2775960820 @default.
• W2606262012 hasConcept C2778229498 @default.
• W2606262012 hasConcept C2780559512 @default.
• W2606262012 hasConcept C55493867 @default.
• W2606262012 hasConcept C62478195 @default.

• next