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- W2606276269 startingPage "1173" @default.
- W2606276269 abstract "Compounds were tested for the activity of decreasing the capillary fragility by the prevention of pulmonary hemorrhage in mice under reduced pressure. Compounds effective were found to be natural, quercetin, 2, 3-dihydroquercetin, rutin, hesperidin, myricitrin and myricetin, and the synthetic 3′, 4′-dihydroxyflavonol, 6-chloro-3′, 4′-dihydroxyflavonol, 6-methyl-3′, 4′-dihydroxyflavonol and water-soluble 3′, 4′-dihydroxyflavonol-SO3Na, of which, 3′, 4′-dihydroxyflavonol was the most effective. It was assumed that for a compound to be effective as a capillary stabilizer, it was necessary for the flavonols or flavones to possess vicinal hydroxyls in the 3′- and 4′-positions, and a hydroxyl at 3-and a carbonyl at 4-position, since the methylation or acetylation of this hydroxyl decreases or obliterates this efficacy." @default.
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- W2606276269 date "1951-01-01" @default.
- W2606276269 modified "2023-10-14" @default.
- W2606276269 title "Pharmacological and Chemical Studies on Rutin-like Compounds. I" @default.
- W2606276269 doi "https://doi.org/10.1248/yakushi1947.71.11_1173" @default.
- W2606276269 hasPublicationYear "1951" @default.
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