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- W2606313308 abstract "Fluoroquinolones are broad-spectrum antimicrobials which are widely used in clinical medicine. Unfortunately, the worldwide emergence of resistance mechanisms against these antibiotics has decreased their value in clinical therapy. Apart from the resistance mediated by chromosomal mutations, in 1998 the first plasmid-mediated quinolone resistance (PMQR) gene was described and labelled qnrA (Martinez-Martinez et al., 1998). Since then, seven different PMQR determinants have been found in Enterobacteriaceae isolates: qnrA, qnrB, qnrC, qnrD, qnrS, aac(6´)-Ib-cr and qepA (Martinez-Martinez et al., 1998; Hata et al., 2005; Jacoby et al., 2006; Robicsek et al., 2006;Yamane et al., 2007; Cavaco et al., 2009; Wang et al., 2009).Until now qnrC has only been discovered in a single isolate of Proteus mirabilis of clinical origin in China (Wang et al., 2009). This gene encodes a 221 amino-acid protein (QnrC) which shares amino acid identities between 64% and 42% with the other Qnr proteins. The present work firstly describes the detection of two qnrC-positive E. coli isolates from livestock animals in Germany." @default.
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- W2606313308 date "2010-01-01" @default.
- W2606313308 modified "2023-09-24" @default.
- W2606313308 title "Detection of qnrC in two ESBL-positive Escherichia coli isolates originated from animals in Germany" @default.
- W2606313308 hasPublicationYear "2010" @default.
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