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• W2606333862 startingPage "55" @default.
• W2606333862 abstract "Infliction of DNA damage initiates a complex cellular reaction – the DNA damage response – that involves both signaling and DNA repair networks with many redundancies and parallel pathways. Here, we reveal the three strategies that the simple multicellular eukaryote, C. elegans, uses to deal with DNA damage induced by light. Separately inactivating repair or replicative bypass of photo-lesions results in cellular hypersensitivity towards UV-light, but impeding repair of replication associated DNA breaks does not. Yet, we observe an unprecedented synergistic relationship when these pathways are inactivated in combination. C. elegans mutants that lack nucleotide excision repair (NER), translesion synthesis (TLS) and alternative end joining (altEJ) grow undisturbed in the dark, but become sterile when grown in light. Even exposure to very low levels of normal daylight impedes animal growth. We show that NER and TLS operate to suppress the formation of lethal DNA breaks that require polymerase theta-mediated end joining (TMEJ) for their repair. Our data testifies to the enormous genotoxicity of light and to the demand of multiple layers of protection against an environmental threat that is so common." @default.
• W2606333862 created "2017-04-28" @default.
• W2606333862 creator A5015598718 @default.
• W2606333862 creator A5060457182 @default.
• W2606333862 date "2017-06-01" @default.
• W2606333862 modified "2023-09-26" @default.
• W2606333862 title "Combined loss of three DNA damage response pathways renders C. elegans intolerant to light" @default.
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• W2606333862 doi "https://doi.org/10.1016/j.dnarep.2017.04.002" @default.
• W2606333862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28472716" @default.
• W2606333862 hasPublicationYear "2017" @default.
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