FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606348538> ?p ?o ?g. }

• W2606348538 endingPage "55" @default.
• W2606348538 startingPage "44" @default.
• W2606348538 abstract "The renin angiotensin system (RAS) regulates numerous systemic functions and is expressed locally in skeletal tissues. Angiotensin1-7 (Ang1-7) is a beneficial member of the RAS, and the therapeutic effects of a large number of angiotensin receptors blockers (ARBs) are mediated by an Ang1-7-dependent cascade. This study examines whether the reported osteo-preservative effects of losartan are mediated through the angiotensin converting enzyme2 (ACE-2)/Ang1-7/Mas pathway in ovariectomized (OVX) rats. Sham and OVX animals received losartan (10 mg/kg/d p.o.) for 6 weeks. A specific Mas receptor blocker (A-779) was delivered via mini-osmotic pumps during the losartan treatment period. Serum and urine bone metabolism biomarker levels were measured. Bone trabecular and cortical morphometry were quantified in distal femurs, whereas mineral contents were estimated in ashed bones, serum and urine. Finally, the expression of RAS components, the receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) was determined. Losartan significantly improved the elevated bone metabolism marker levels and altered trabecular and cortical structures in OVX animals, and restored normal urinary and skeletal mineral levels. Mas receptor inhibition significantly abolished all osteo-protective effects of losartan and enhanced the deleterious effects of OVX. Losartan enhanced OVX-induced up-regulation of ACE-1, AngII, angiotensin type 1 (AT1) receptor and RANKL expression, and increased ACE-2, Ang1-7, Mas and OPG expression in OVX animals. However, A-779 significantly eradicated the effects of losartan on RAS components and RANKL/OPG expression. Thus, Ang1-7 are involved in the osteo-preservative effects of losartan via Mas receptor, which may add therapeutic value to this well-known antihypertensive agent." @default.
• W2606348538 created "2017-04-28" @default.
• W2606348538 creator A5073244900 @default.
• W2606348538 creator A5075806040 @default.
• W2606348538 creator A5078368929 @default.
• W2606348538 creator A5082927666 @default.
• W2606348538 creator A5086723240 @default.
• W2606348538 date "2017-07-01" @default.
• W2606348538 modified "2023-10-17" @default.
• W2606348538 title "The ACE-2/Ang1-7/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade" @default.
• W2606348538 cites W1128592731 @default.
• W2606348538 cites W1821554906 @default.
• W2606348538 cites W1835263404 @default.
• W2606348538 cites W1970020309 @default.
• W2606348538 cites W1973924370 @default.
• W2606348538 cites W1977154139 @default.
• W2606348538 cites W1979532594 @default.
• W2606348538 cites W1994185503 @default.
• W2606348538 cites W2000040025 @default.
• W2606348538 cites W2003158379 @default.
• W2606348538 cites W2008614129 @default.
• W2606348538 cites W2009871776 @default.
• W2606348538 cites W2015660898 @default.
• W2606348538 cites W2021400723 @default.
• W2606348538 cites W2024594848 @default.
• W2606348538 cites W2034389648 @default.
• W2606348538 cites W2034950271 @default.
• W2606348538 cites W2050940500 @default.
• W2606348538 cites W2053286287 @default.
• W2606348538 cites W2058662881 @default.
• W2606348538 cites W2064898327 @default.
• W2606348538 cites W2064930270 @default.
• W2606348538 cites W2069893575 @default.
• W2606348538 cites W2075877355 @default.
• W2606348538 cites W2106321093 @default.
• W2606348538 cites W2107093217 @default.
• W2606348538 cites W2108783129 @default.
• W2606348538 cites W2110641811 @default.
• W2606348538 cites W2111471786 @default.
• W2606348538 cites W2117322911 @default.
• W2606348538 cites W2119244437 @default.
• W2606348538 cites W2123048269 @default.
• W2606348538 cites W2125403039 @default.
• W2606348538 cites W2128177515 @default.
• W2606348538 cites W2146375144 @default.
• W2606348538 doi "https://doi.org/10.1016/j.ejphar.2017.04.031" @default.
• W2606348538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28442323" @default.
• W2606348538 hasPublicationYear "2017" @default.
• W2606348538 type Work @default.
• W2606348538 sameAs 2606348538 @default.
• W2606348538 citedByCount "25" @default.
• W2606348538 countsByYear W26063485382017 @default.
• W2606348538 countsByYear W26063485382018 @default.
• W2606348538 countsByYear W26063485382019 @default.
• W2606348538 countsByYear W26063485382020 @default.
• W2606348538 countsByYear W26063485382021 @default.
• W2606348538 countsByYear W26063485382022 @default.
• W2606348538 countsByYear W26063485382023 @default.
• W2606348538 crossrefType "journal-article" @default.
• W2606348538 hasAuthorship W2606348538A5073244900 @default.
• W2606348538 hasAuthorship W2606348538A5075806040 @default.
• W2606348538 hasAuthorship W2606348538A5078368929 @default.
• W2606348538 hasAuthorship W2606348538A5082927666 @default.
• W2606348538 hasAuthorship W2606348538A5086723240 @default.
• W2606348538 hasConcept C104849204 @default.
• W2606348538 hasConcept C123915805 @default.
• W2606348538 hasConcept C126322002 @default.
• W2606348538 hasConcept C134018914 @default.
• W2606348538 hasConcept C170033053 @default.
• W2606348538 hasConcept C170493617 @default.
• W2606348538 hasConcept C185592680 @default.
• W2606348538 hasConcept C198710026 @default.
• W2606348538 hasConcept C2779428903 @default.
• W2606348538 hasConcept C2780288358 @default.
• W2606348538 hasConcept C2780426850 @default.
• W2606348538 hasConcept C2908929049 @default.
• W2606348538 hasConcept C71924100 @default.
• W2606348538 hasConcept C84393581 @default.
• W2606348538 hasConcept C88045685 @default.
• W2606348538 hasConceptScore W2606348538C104849204 @default.
• W2606348538 hasConceptScore W2606348538C123915805 @default.
• W2606348538 hasConceptScore W2606348538C126322002 @default.
• W2606348538 hasConceptScore W2606348538C134018914 @default.
• W2606348538 hasConceptScore W2606348538C170033053 @default.
• W2606348538 hasConceptScore W2606348538C170493617 @default.
• W2606348538 hasConceptScore W2606348538C185592680 @default.
• W2606348538 hasConceptScore W2606348538C198710026 @default.
• W2606348538 hasConceptScore W2606348538C2779428903 @default.
• W2606348538 hasConceptScore W2606348538C2780288358 @default.
• W2606348538 hasConceptScore W2606348538C2780426850 @default.
• W2606348538 hasConceptScore W2606348538C2908929049 @default.
• W2606348538 hasConceptScore W2606348538C71924100 @default.
• W2606348538 hasConceptScore W2606348538C84393581 @default.
• W2606348538 hasConceptScore W2606348538C88045685 @default.
• W2606348538 hasLocation W26063485381 @default.
• W2606348538 hasLocation W26063485382 @default.
• W2606348538 hasOpenAccess W2606348538 @default.
• W2606348538 hasPrimaryLocation W26063485381 @default.

• next