Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606368577> ?p ?o ?g. }
- W2606368577 abstract "ABSTRACT The antibody repertoire is a vast and diverse collection of B-cell receptors and antibodies that confer protection against a plethora of pathogens. The architecture of the antibody repertoire, defined by the network similarity landscape of its sequences, is unknown. Here, we established a novel high-performance computing platform to construct large-scale networks from high-throughput sequencing data (>100’000 unique antibodies), in order to uncover the architecture of antibody repertoires. We identified three fundamental principles of antibody repertoire architecture across B-cell development: reproducibility, robustness and redundancy. Reproducibility of network structure explains clonal expansion and selection. Robustness ensures a functional immune response even under extensive loss of clones (50%). Redundancy in mutational pathways suggests that there is a pre-programmed evolvability in antibody repertoires. Our analysis provides guidelines for a quantitative network analysis of antibody repertoires, which can be applied to other facets of adaptive immunity (e.g., T cell receptors), and may direct the construction of synthetic repertoires for biomedical applications." @default.
- W2606368577 created "2017-04-28" @default.
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- W2606368577 date "2017-04-05" @default.
- W2606368577 modified "2023-09-23" @default.
- W2606368577 title "The fundamental principles of antibody repertoire architecture revealed by large-scale network analysis" @default.
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- W2606368577 doi "https://doi.org/10.1101/124578" @default.
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