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- W2606408744 abstract "Abstract The RIG ‐I receptors RIG ‐I, MDA 5 and LGP 2 are involved in viral recognition, and they have different ligand specificity and recognize different viruses. Activation of RIG‐I‐like receptors ( RLR s) leads to production of cytokines essential for antiviral immunity. In fish, most research has focused on interferons, and less is known about the production of proinflammatory cytokines during viral infections. In this study, we have cloned the full‐length MDA 5 sequence in Atlantic salmon, and compared it with RIG ‐I and LGP 2. Further, the salmonid cell line TO was infected with three fish pathogenic viruses, infectious pancreatic necrosis virus ( IPNV ), infectious salmon anaemia virus ( ISAV ) and salmonid alphavirus ( SAV ), and differential gene expression ( DEG ) analyses of RLR s, interferons ( IFN a‐d) and proinflammatory cytokines ( TNF ‐α1, TNF ‐α2, IL ‐1β, IL ‐6, IL ‐12 p40s) were performed. The DEG analyses showed that the responses of proinflammatory cytokines in TO cells infected with IPNV and ISAV were profoundly different from SAV ‐infected cells. In the two aforementioned, TNF ‐α1 and TNF ‐α2 were highly upregulated, while in SAV ‐infected cells these cytokines were downregulated. Knowledge of virus recognition by the host and the immune responses during infection may help elucidate why and how some viruses can escape the immune system. Such knowledge is useful for the development of immune prophylactic measures." @default.
- W2606408744 created "2017-04-28" @default.
- W2606408744 creator A5003501710 @default.
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- W2606408744 creator A5090394777 @default.
- W2606408744 date "2017-04-21" @default.
- W2606408744 modified "2023-09-26" @default.
- W2606408744 title "Molecular cloning of MDA5, phylogenetic analysis of RIG-I-like receptors (RLRs) and differential gene expression of RLRs, interferons and proinflammatory cytokines after <i>in vitro</i> challenge with IPNV, ISAV and SAV in the salmonid cell line TO" @default.
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- W2606408744 doi "https://doi.org/10.1111/jfd.12622" @default.
- W2606408744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28429853" @default.
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