Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606438863> ?p ?o ?g. }
- W2606438863 abstract "γ-Secretase cleavage of the Notch receptor transmembrane domain is a critical signaling event for various cellular processes. Efforts to develop inhibitors of γ-secretase cleavage of the amyloid-β precursor C99 protein as potential Alzheimer's disease therapeutics have been confounded by toxicity resulting from the inhibition of normal cleavage of Notch. We present biochemical and structural data for the combined transmembrane and juxtamembrane Notch domains (Notch-TMD) that illuminate Notch signaling and that can be compared and contrasted with the corresponding traits of C99. The Notch-TMD and C99 have very different conformations, adapt differently to changes in model membrane hydrophobic span, and exhibit different cholesterol-binding properties. These differences may be exploited in the design of agents that inhibit cleavage of C99 while allowing Notch cleavage." @default.
- W2606438863 created "2017-04-28" @default.
- W2606438863 creator A5002108035 @default.
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- W2606438863 creator A5042411947 @default.
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- W2606438863 creator A5082570613 @default.
- W2606438863 creator A5085213605 @default.
- W2606438863 date "2017-04-07" @default.
- W2606438863 modified "2023-10-14" @default.
- W2606438863 title "Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains" @default.
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