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• W2606443087 abstract "3207 Introduction: BRCA1/2 mutation carriers have up to 80 % lifetime risk of developing breast cancer and 20 to 40% risk of developing ovarian cancer. The risk factors for breast and ovarian cancer pertaining to the general population may not always apply to BRCA1 mutation carriers. For example, BRCA1 mutation carriers are especially sensitive to oral contraceptive (OC) use and pregnancy with respect to early-onset breast cancer, and the protective effect from OC use on ovarian cancer is unclear. High LH levels have been linked to increased risks of both breast and ovarian cancers and it is unknown whether gonadotropin levels are associated with BRCA1 mutation status. Methods: The aim of the study was to explore whether gonadotropin levels were associated with BRCA1 mutation status among healthy 18 to 40 year-old women from hereditary breast cancer families. All women completed a questionnaire including information on reproductive factors and OC use. We measured height, weight, breast volumes and plasma luteinizing hormone (LH), follicular stimulating hormone (FSH) and estradiol (E2) levels once during menstrual cycle days 5 to 10 and once again during cycle days 18 to 23 in 41 non-carriers from BRCA1 families, 20 BRCA1 mutation carriers and 102 women from non-BRCA1/2 families. Results: The strongest predictors of high LH levels among BRCA1 mutation carriers and non-carriers during cycle days 5 to 10 were being a BRCA1 mutation carrier (p = 0.003), lack of current OC use (p = 0.003), and being nulliparous (p = 0.01), adjusted for age and menstrual cycle day when the samples were obtained. This association was seen both in non-OC users and current OC users but was only significant in the former group. FSH and E2 were similar in non-carriers, BRCA1 mutation carriers and women from non-BRCA1/2 families. Conclusion: We found significantly elevated LH levels in the follicular phase among young healthy BRCA1 mutation carriers compared with non-carriers from BRCA1 families. This is a small study and confirmatory studies are warranted to establish whether elevated LH levels are part of the BRCA1 phenotype and may be manipulated in order to reduce cancer risks in BRCA1 mutation carriers." @default.
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• W2606443087 date "2005-05-01" @default.
• W2606443087 modified "2023-09-26" @default.
• W2606443087 title "High follicular phase Luteinizing Hormone levels in young healthy BRCA1 mutation carriers: implications for breast and ovarian cancer risk" @default.
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