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• W2606458370 startingPage "e201700029" @default.
• W2606458370 abstract "In an effort to develop new fluoroquinolones, we synthesized eight compounds and tested them against a panel of bacteria. The design of these compounds was guided by the introduction of the isothiazoloquinolone motif. The three most active compounds in this series, 8–10, demonstrated good antibacterial activity against methicillin-sensitive Staphylococcus aureus and healthcare-acquired methicillin-resistant Staphylococcus aureus (MIC 0.62–6.3 µg/mL). Further, when these three active compounds were tested for their inhibitory effects on bacterial enzymes, compound 9 was the most effective agent exhibiting IC50 values of 33.9 and 116.5 μM in the S. aureus deoxyribonucleic acid (DNA) gyrase supercoiling and topoisomerase IV decatenation assays, respectively." @default.
• W2606458370 created "2017-04-28" @default.
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• W2606458370 date "2017-04-21" @default.
• W2606458370 modified "2023-09-23" @default.
• W2606458370 title "Synthesis and Evaluation of Thiazolidine Amide and <i>N</i> -Thiazolyl Amide Fluoroquinolone Derivatives" @default.
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• W2606458370 doi "https://doi.org/10.1002/ardp.201700029" @default.
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