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- W2606559675 abstract "We haveanalyzed theeffect ofDNA intercalating agents on thetranscription signals fromtwodifferent Xenopus laevis RNA polymerase Ipromoters. Thetranscription signal fromthepromoterforthe7.5-kilobase rRNAprecursor(the gene promoter) isunaffected over a large range ofintercalating agentconcentrations regardless ofwhether thetemplate isinjected plasmid DNA inoocytes, theamplified endogenous nucleoli of oocytes, or theendogenous chromosomes ofcultured Xenopuskidney cells. Thetranscription signal froma closely related promoterlocated inthespacerDNA between genes (the spacer promoter) ranges between undetectable toequivalent tothegenepromotersignal ondifferent templates. Thetranscription signal fromthe spacerpromoterisalso differentially affected byintercalating agentsrelative tothegene promoter. Depending onthetemplate, these agents caneither increase ordecrease thetranscription signal fromthespacerpromoter. Fusions between thegene andspacerpromoters demonstrate thatintercalating agentsaffect transcription initiation. Oneexplanation forthese results isthatthedegree ofsupercoiling ofthetemplate DNA can differentially inhibit transcription fromthespacerpromoters. Thedifferent effects ofintercalating agents on transcription fromthespacerpromoters ofvarious templates couldthenbeexplained as differences inthe degree ofsupercoiling present on these templates initially. Eachrepeating unit ofXenopus laevis rDNAcontains two typesofRNA polymerase Ipromoter:thepromoterfor transcription ofthe7.5-kilobase rRNA precursor(the gene promoter) andtwoor more homologous sequenceslocated inthespacerDNA between genes(the spacerpromoters). Thegene promoterhasbeenlocalized tothesequences between-142and+6relative tothetranscription initiation site(5,20).Sixdifferent spacerpromotershavebeensequenced andall arenearly identical toeachother. However, theyalldiffer fromthegenepromoterinapproximately 15 positions (4a, 7,8,19)." @default.
- W2606559675 created "2017-04-28" @default.
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- W2606559675 date "1984-01-01" @default.
- W2606559675 modified "2023-09-23" @default.
- W2606559675 title "Effect ofIntercalating Agents on RNA Polymerase IPromoter Selection inXenopuslaevis" @default.
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- W2606559675 hasPublicationYear "1984" @default.
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