Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606560636> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2606560636 endingPage "20" @default.
- W2606560636 startingPage "12" @default.
- W2606560636 abstract "Drug delivery to the brain is still a major challenge in the field of therapeutics, especially for large and hydrophilic compounds. In order to achieve drug delivery of therapeutic concentration in the central nervous system, the problematic blood brain barrier (BBB) must be overcome. This work presents the formulation of a targeted nanoparticle-based drug delivery system using a specific neural cell targeting ligand, rabies virus derived peptide (RDP). Characterization studies revealed that RDP could be conjugated to drug-loaded PLGA nanoparticles of average diameter 257.10±22.39nm and zeta potential of -5.51±0.73mV. In vitro studies showed that addition of RDP to nanoparticles enhanced drug accumulation in a neural cell line specifically as opposed to non-neural cell lines. It was revealed that this drug delivery system is reliant upon nicotinic acetylcholine receptor (nAChR) function for RDP-facilitated effects, supporting a cellular uptake mechanism of action. The specific neural cell targeting capabilities of RDP via the nAChR offers a non-toxic, non-invasive and promising approach to the delivery of therapeutics to the brain." @default.
- W2606560636 created "2017-04-28" @default.
- W2606560636 creator A5016206187 @default.
- W2606560636 creator A5032378248 @default.
- W2606560636 creator A5087762311 @default.
- W2606560636 creator A5090257452 @default.
- W2606560636 date "2017-06-01" @default.
- W2606560636 modified "2023-10-16" @default.
- W2606560636 title "Targeted drug delivery system to neural cells utilizes the nicotinic acetylcholine receptor" @default.
- W2606560636 cites W1992498787 @default.
- W2606560636 cites W1993456710 @default.
- W2606560636 cites W2000381333 @default.
- W2606560636 cites W2002946590 @default.
- W2606560636 cites W2004750142 @default.
- W2606560636 cites W2007506596 @default.
- W2606560636 cites W2020398834 @default.
- W2606560636 cites W2034586091 @default.
- W2606560636 cites W2050181086 @default.
- W2606560636 cites W2070693578 @default.
- W2606560636 cites W2081365179 @default.
- W2606560636 cites W2082361867 @default.
- W2606560636 cites W2089597120 @default.
- W2606560636 cites W2091546373 @default.
- W2606560636 cites W2103616205 @default.
- W2606560636 cites W2108272887 @default.
- W2606560636 cites W2116962130 @default.
- W2606560636 cites W2130622756 @default.
- W2606560636 cites W2142388167 @default.
- W2606560636 cites W2159537966 @default.
- W2606560636 cites W2164032925 @default.
- W2606560636 cites W2326573831 @default.
- W2606560636 doi "https://doi.org/10.1016/j.ijpharm.2017.04.023" @default.
- W2606560636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28412449" @default.
- W2606560636 hasPublicationYear "2017" @default.
- W2606560636 type Work @default.
- W2606560636 sameAs 2606560636 @default.
- W2606560636 citedByCount "16" @default.
- W2606560636 countsByYear W26065606362017 @default.
- W2606560636 countsByYear W26065606362018 @default.
- W2606560636 countsByYear W26065606362019 @default.
- W2606560636 countsByYear W26065606362020 @default.
- W2606560636 countsByYear W26065606362021 @default.
- W2606560636 countsByYear W26065606362023 @default.
- W2606560636 crossrefType "journal-article" @default.
- W2606560636 hasAuthorship W2606560636A5016206187 @default.
- W2606560636 hasAuthorship W2606560636A5032378248 @default.
- W2606560636 hasAuthorship W2606560636A5087762311 @default.
- W2606560636 hasAuthorship W2606560636A5090257452 @default.
- W2606560636 hasBestOaLocation W26065606362 @default.
- W2606560636 hasConcept C126511603 @default.
- W2606560636 hasConcept C170493617 @default.
- W2606560636 hasConcept C178790620 @default.
- W2606560636 hasConcept C185592680 @default.
- W2606560636 hasConcept C188987157 @default.
- W2606560636 hasConcept C2779570518 @default.
- W2606560636 hasConcept C2779820397 @default.
- W2606560636 hasConcept C2780035454 @default.
- W2606560636 hasConcept C55493867 @default.
- W2606560636 hasConcept C86803240 @default.
- W2606560636 hasConcept C98274493 @default.
- W2606560636 hasConceptScore W2606560636C126511603 @default.
- W2606560636 hasConceptScore W2606560636C170493617 @default.
- W2606560636 hasConceptScore W2606560636C178790620 @default.
- W2606560636 hasConceptScore W2606560636C185592680 @default.
- W2606560636 hasConceptScore W2606560636C188987157 @default.
- W2606560636 hasConceptScore W2606560636C2779570518 @default.
- W2606560636 hasConceptScore W2606560636C2779820397 @default.
- W2606560636 hasConceptScore W2606560636C2780035454 @default.
- W2606560636 hasConceptScore W2606560636C55493867 @default.
- W2606560636 hasConceptScore W2606560636C86803240 @default.
- W2606560636 hasConceptScore W2606560636C98274493 @default.
- W2606560636 hasFunder F4320320319 @default.
- W2606560636 hasIssue "1" @default.
- W2606560636 hasLocation W26065606361 @default.
- W2606560636 hasLocation W26065606362 @default.
- W2606560636 hasLocation W26065606363 @default.
- W2606560636 hasLocation W26065606364 @default.
- W2606560636 hasLocation W26065606365 @default.
- W2606560636 hasOpenAccess W2606560636 @default.
- W2606560636 hasPrimaryLocation W26065606361 @default.
- W2606560636 hasRelatedWork W1988784801 @default.
- W2606560636 hasRelatedWork W1991750263 @default.
- W2606560636 hasRelatedWork W2005196200 @default.
- W2606560636 hasRelatedWork W2047564837 @default.
- W2606560636 hasRelatedWork W2809228924 @default.
- W2606560636 hasRelatedWork W3041384410 @default.
- W2606560636 hasRelatedWork W3157244191 @default.
- W2606560636 hasRelatedWork W3215128417 @default.
- W2606560636 hasRelatedWork W4381335604 @default.
- W2606560636 hasRelatedWork W2184708330 @default.
- W2606560636 hasVolume "525" @default.
- W2606560636 isParatext "false" @default.
- W2606560636 isRetracted "false" @default.
- W2606560636 magId "2606560636" @default.
- W2606560636 workType "article" @default.