FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606576211> ?p ?o ?g. }

• W2606576211 endingPage "5200" @default.
• W2606576211 startingPage "5193" @default.
• W2606576211 abstract "Polyethylene glycols (PEGs) are synthetic polymers composed of repeating ethylene oxide subunits. They display excellent biocompatibility and are widely used as pharmaceutical excipients. To fully understand the biological fate of PEGs requires accurate and sensitive analytical methods for their quantitation. Application of conventional liquid chromatography-tandem mass spectrometry (LC-MS/MS) is difficult because PEGs have polydisperse molecular weights (MWs) and tend to produce multicharged ions in-source resulting in innumerable precursor ions. As a result, multiple reaction monitoring (MRM) fails to scan all ion pairs so that information on the fate of unselected ions is missed. This Article addresses this problem by application of liquid chromatography-triple-quadrupole/time-of-flight mass spectrometry (LC-Q-TOF MS) based on the MSALL technique. This technique performs information-independent acquisition by allowing all PEG precursor ions to enter the collision cell (Q2). In-quadrupole collision-induced dissociation (CID) in Q2 then effectively generates several fragments from all PEGs due to the high collision energy (CE). A particular PEG product ion (m/z 133.08592) was found to be common to all linear PEGs and allowed their total quantitation in rat plasma with high sensitivity, excellent linearity and reproducibility. Assay validation showed the method was linear for all linear PEGs over the concentration range 0.05-5.0 μg/mL. The assay was successfully applied to the pharmacokinetic study in rat involving intravenous administration of linear PEG 600, PEG 4000, and PEG 20000. It is anticipated the method will have wide ranging applications and stimulate the development of assays for other pharmaceutical polymers in the future." @default.
• W2606576211 created "2017-04-28" @default.
• W2606576211 creator A5002318044 @default.
• W2606576211 creator A5034927324 @default.
• W2606576211 creator A5036399214 @default.
• W2606576211 creator A5038556283 @default.
• W2606576211 creator A5042316902 @default.
• W2606576211 creator A5060412535 @default.
• W2606576211 creator A5063035403 @default.
• W2606576211 creator A5073808601 @default.
• W2606576211 creator A5079705305 @default.
• W2606576211 creator A5084243345 @default.
• W2606576211 date "2017-04-26" @default.
• W2606576211 modified "2023-10-16" @default.
• W2606576211 title "Development and Application of an MS^ALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry" @default.
• W2606576211 cites W1070192648 @default.
• W2606576211 cites W1561844029 @default.
• W2606576211 cites W1949434334 @default.
• W2606576211 cites W1966314215 @default.
• W2606576211 cites W1975423250 @default.
• W2606576211 cites W1979723442 @default.
• W2606576211 cites W2000597410 @default.
• W2606576211 cites W2000938071 @default.
• W2606576211 cites W2010506651 @default.
• W2606576211 cites W2014108020 @default.
• W2606576211 cites W2014590342 @default.
• W2606576211 cites W2025614072 @default.
• W2606576211 cites W2025748945 @default.
• W2606576211 cites W2034067478 @default.
• W2606576211 cites W2039477628 @default.
• W2606576211 cites W2042407285 @default.
• W2606576211 cites W2048769968 @default.
• W2606576211 cites W2055899061 @default.
• W2606576211 cites W2060236861 @default.
• W2606576211 cites W2068087618 @default.
• W2606576211 cites W2080330214 @default.
• W2606576211 cites W2085534679 @default.
• W2606576211 cites W2085835429 @default.
• W2606576211 cites W2087842405 @default.
• W2606576211 cites W2090213264 @default.
• W2606576211 cites W2092848002 @default.
• W2606576211 cites W2098602548 @default.
• W2606576211 cites W2110100391 @default.
• W2606576211 cites W2121171062 @default.
• W2606576211 cites W2122364598 @default.
• W2606576211 cites W2124157967 @default.
• W2606576211 cites W2150895058 @default.
• W2606576211 cites W2154157119 @default.
• W2606576211 cites W2156492800 @default.
• W2606576211 cites W2163598989 @default.
• W2606576211 cites W2164841185 @default.
• W2606576211 cites W2195209480 @default.
• W2606576211 cites W2319376287 @default.
• W2606576211 cites W2325790065 @default.
• W2606576211 cites W2413581371 @default.
• W2606576211 cites W2423156953 @default.
• W2606576211 cites W80378057 @default.
• W2606576211 doi "https://doi.org/10.1021/acs.analchem.6b04058" @default.
• W2606576211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28418637" @default.
• W2606576211 hasPublicationYear "2017" @default.
• W2606576211 type Work @default.
• W2606576211 sameAs 2606576211 @default.
• W2606576211 citedByCount "24" @default.
• W2606576211 countsByYear W26065762112018 @default.
• W2606576211 countsByYear W26065762112019 @default.
• W2606576211 countsByYear W26065762112020 @default.
• W2606576211 countsByYear W26065762112021 @default.
• W2606576211 countsByYear W26065762112022 @default.
• W2606576211 countsByYear W26065762112023 @default.
• W2606576211 crossrefType "journal-article" @default.
• W2606576211 hasAuthorship W2606576211A5002318044 @default.
• W2606576211 hasAuthorship W2606576211A5034927324 @default.
• W2606576211 hasAuthorship W2606576211A5036399214 @default.
• W2606576211 hasAuthorship W2606576211A5038556283 @default.
• W2606576211 hasAuthorship W2606576211A5042316902 @default.
• W2606576211 hasAuthorship W2606576211A5060412535 @default.
• W2606576211 hasAuthorship W2606576211A5063035403 @default.
• W2606576211 hasAuthorship W2606576211A5073808601 @default.
• W2606576211 hasAuthorship W2606576211A5079705305 @default.
• W2606576211 hasAuthorship W2606576211A5084243345 @default.
• W2606576211 hasConcept C10138342 @default.
• W2606576211 hasConcept C106289968 @default.
• W2606576211 hasConcept C113196181 @default.
• W2606576211 hasConcept C145148216 @default.
• W2606576211 hasConcept C162324750 @default.
• W2606576211 hasConcept C162356407 @default.
• W2606576211 hasConcept C172493649 @default.
• W2606576211 hasConcept C178790620 @default.
• W2606576211 hasConcept C185592680 @default.
• W2606576211 hasConcept C27826464 @default.
• W2606576211 hasConcept C31827203 @default.
• W2606576211 hasConcept C43617362 @default.
• W2606576211 hasConcept C54400483 @default.
• W2606576211 hasConcept C71043704 @default.
• W2606576211 hasConceptScore W2606576211C10138342 @default.
• W2606576211 hasConceptScore W2606576211C106289968 @default.
• W2606576211 hasConceptScore W2606576211C113196181 @default.
• W2606576211 hasConceptScore W2606576211C145148216 @default.

• next