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- W2606592679 abstract "Abstract Inducing tumour-specific adaptive immunity, such as cytotoxic T lymphocyte (CTL) response, can result in promising antitumour effect against several human malignancies, especially in combination with immune checkpoint blockade strategies. However, little is known whether activation of innate immunity can lead to direct tumoricidal effect. Here, we develop a papilloma pseudovirus-based oral immunotherapeutic approach that shows strong tumoricidal effects in the gut, resulting in an almost tripled lifespan of Apc Min/+ mice (an animal model of human intestinal tumorigenesis). Mechanistically, these pseudoviruses activate the NLRP3 and AIM2 inflammasomes, leading to caspase-1-mediated tumour regression that is dependent on neither cytotoxic T lymphocytes nor humoral immune response. Blocking caspase-1 activation abrogated the therapeutic effects of the pseudoviruses. Thus, targeting innate immune sensors in tumours by the pseudoviruses might represent a strategy to treat intestinal tumours." @default.
- W2606592679 created "2017-04-28" @default.
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- W2606592679 date "2017-04-11" @default.
- W2606592679 modified "2023-10-02" @default.
- W2606592679 title "Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice" @default.
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- W2606592679 doi "https://doi.org/10.1038/ncomms15004" @default.
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