Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606594645> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2606594645 abstract "To restore vision in patients who lost their photoreceptors due to retinal degeneration, we developed a photovoltaic subretinal prosthesis which converts light into pulsed electric current, stimulating the nearby inner retinal neurons. Visual information is projected onto the retina by video goggles using pulsed near-infrared (~900nm) light. This design avoids the use of bulky electronics and wiring, thereby greatly reducing the surgical complexity. Optical activation of the photovoltaic pixels allows scaling the implants to thousands of electrodes, and multiple modules can be tiled under the retina to expand the visual field.We found that similarly to normal vision, retinal response to prosthetic stimulation exhibits flicker fusion at high frequencies (>20Hz), adaptation to static images, and non-linear summation of subunits in the receptive fields. Photovoltaic arrays with 70um pixels restored visual acuity up to a single pixel pitch, which is only two times lower than natural acuity in rats. If these results translate to human retina, such implants could restore visual acuity up to 20/250. With eye scanning and perceptual learning, human patients might even cross the 20/200 threshold of legal blindness. In collaboration with Pixium Vision, we are preparing this system (PRIMA) for a clinical trial. To further improve visual acuity, we are developing smaller pixels – down to 40um, and on 3-D interface to improve proximity to the target neurons. Scalability, ease of implantation and tiling of these wireless modules to cover a large visual field, combined with high resolution opens the door to highly functional restoration of sight." @default.
- W2606594645 created "2017-04-28" @default.
- W2606594645 creator A5064040602 @default.
- W2606594645 date "2017-04-19" @default.
- W2606594645 modified "2023-09-25" @default.
- W2606594645 title "Photovoltaic restoration of sight in rodents with retinal degeneration (Conference Presentation)" @default.
- W2606594645 doi "https://doi.org/10.1117/12.2250427" @default.
- W2606594645 hasPublicationYear "2017" @default.
- W2606594645 type Work @default.
- W2606594645 sameAs 2606594645 @default.
- W2606594645 citedByCount "1" @default.
- W2606594645 countsByYear W26065946452018 @default.
- W2606594645 crossrefType "proceedings-article" @default.
- W2606594645 hasAuthorship W2606594645A5064040602 @default.
- W2606594645 hasConcept C120665830 @default.
- W2606594645 hasConcept C121332964 @default.
- W2606594645 hasConcept C154945302 @default.
- W2606594645 hasConcept C158383150 @default.
- W2606594645 hasConcept C2777093970 @default.
- W2606594645 hasConcept C2778560042 @default.
- W2606594645 hasConcept C31972630 @default.
- W2606594645 hasConcept C41008148 @default.
- W2606594645 hasConceptScore W2606594645C120665830 @default.
- W2606594645 hasConceptScore W2606594645C121332964 @default.
- W2606594645 hasConceptScore W2606594645C154945302 @default.
- W2606594645 hasConceptScore W2606594645C158383150 @default.
- W2606594645 hasConceptScore W2606594645C2777093970 @default.
- W2606594645 hasConceptScore W2606594645C2778560042 @default.
- W2606594645 hasConceptScore W2606594645C31972630 @default.
- W2606594645 hasConceptScore W2606594645C41008148 @default.
- W2606594645 hasLocation W26065946451 @default.
- W2606594645 hasOpenAccess W2606594645 @default.
- W2606594645 hasPrimaryLocation W26065946451 @default.
- W2606594645 hasRelatedWork W157035185 @default.
- W2606594645 hasRelatedWork W1977359673 @default.
- W2606594645 hasRelatedWork W1983904781 @default.
- W2606594645 hasRelatedWork W2008040746 @default.
- W2606594645 hasRelatedWork W2027547973 @default.
- W2606594645 hasRelatedWork W2086550610 @default.
- W2606594645 hasRelatedWork W2089978644 @default.
- W2606594645 hasRelatedWork W2295180691 @default.
- W2606594645 hasRelatedWork W2296379871 @default.
- W2606594645 hasRelatedWork W2603909587 @default.
- W2606594645 hasRelatedWork W2943826590 @default.
- W2606594645 hasRelatedWork W2972212412 @default.
- W2606594645 hasRelatedWork W2973896446 @default.
- W2606594645 hasRelatedWork W3030446426 @default.
- W2606594645 hasRelatedWork W3174002726 @default.
- W2606594645 hasRelatedWork W3199838662 @default.
- W2606594645 hasRelatedWork W330904224 @default.
- W2606594645 hasRelatedWork W37616716 @default.
- W2606594645 hasRelatedWork W58558197 @default.
- W2606594645 hasRelatedWork W2603160582 @default.
- W2606594645 isParatext "false" @default.
- W2606594645 isRetracted "false" @default.
- W2606594645 magId "2606594645" @default.
- W2606594645 workType "article" @default.