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• W2606644793 startingPage "1125" @default.
• W2606644793 abstract "DEAD-box proteins are a class of nonprocessive RNA helicases that dynamically modulate the structure of RNA and ribonucleoprotein complexes (RNPs). However, the precise roles of individual members are not well understood. Work from our laboratory revealed that the DEAD-box protein Dbp2 in Saccharomyces cerevisiae is an active RNA helicase in vitro that functions in transcription by promoting mRNP assembly, repressing cryptic transcription initiation, and regulating long noncoding RNA activity. Interestingly, Dbp2 is also linked to glucose sensing and hexose transporter gene expression. DDX5 is the mammalian ortholog of Dbp2 that has been implicated in cancer and metabolic syndrome, suggesting that the role of Dbp2 and DDX5 in glucose metabolic regulation is conserved. Herein, we present a refined biochemical and biological comparison of yeast Dbp2 and human DDX5 enzymes. We find that human DDX5 possesses a 10-fold higher unwinding activity than Dbp2, which is partially due to the presence of a mammalian/avian specific C-terminal extension. Interestingly, ectopic expression of DDX5 rescues the cold sensitivity, cryptic initiation defects, and impaired glucose import in dbp2 Δ cells, suggesting functional conservation. Consistently, we show that DDX5 promotes glucose uptake and glycolysis in mouse AML12 hepatocyte cells, suggesting that mammalian DDX5 and S. cerevisiae Dbp2 share conserved roles in cellular metabolism." @default.
• W2606644793 created "2017-04-28" @default.
• W2606644793 creator A5026296707 @default.
• W2606644793 creator A5061904626 @default.
• W2606644793 creator A5073852332 @default.
• W2606644793 date "2017-04-14" @default.
• W2606644793 modified "2023-10-17" @default.
• W2606644793 title "Characterization of the mammalian DEAD-box protein DDX5 reveals functional conservation with <i>S. cerevisiae</i> ortholog Dbp2 in transcriptional control and glucose metabolism" @default.
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• W2606644793 doi "https://doi.org/10.1261/rna.060335.116" @default.
• W2606644793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5473146" @default.
• W2606644793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28411202" @default.
• W2606644793 hasPublicationYear "2017" @default.
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